The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 129)
Program-non-specific Funding, 2009
Synthesizing biomedical data into effective discoveries is greatly hampered by the way science is both reported in research articles and stored in databases. Articles do not present raw data in an accessible or understandable form and scientific databases are highly specialized, designed only to store one kind of data. Our objective is to develop generic, next-generation scie...
Therapeutics Development Initiative, 2009
The blood-brain barrier (BBB) allows only a small fraction of systemically administered small-molecule drugs and even fewer biopharmaceuticals developed for disorders of the central nervous system (CNS) to reach therapeutic concentrations in the brain. Therefore, bypassing the BBB by direct infusion into the CNS offers a unique means of controlled and targeted delivery of the...
Researchers: Lisa Shafer, PhD
MJFF Research Grant, 2009
This project will aim to establish the behavioral and neuroanatomical correlates of injecting a viral vector that overexpresses the gene for alpha-synuclein into the brains of non-human primate pre-clinical models of PD. Alpha-synuclein is a protein whose mutation or overexpression is believed to play a role in Parkinson’s disease in humans. In rodents, injecting a virus that ...
Researchers: Jeffrey H. Kordower, PhD
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2009
Alpha-synuclein is a protein that is found in nerve cells of patients with PD and therefore provides a potential target for methods designed to monitor the disease process in PD. We plan to modify a small protein custom made to tag alpha-synuclein so that we can develop a brain imaging radiotracer for PD diagnosis and progression. This imaging tool could also be used to help ...
Rapid Response Innovation Awards, 2009
The most common hereditary form of Parkinson’s Disease (PD) results from mutations of the LRRK2 gene in humans. The model genetic organism, Drosophila melanogaster (fruit fly), possess a very similar gene called dLRRK.Given the evolutionary conservation of the human and fly LRRK genes, we propose to utilize the power and pace of Drosophila genetics to introduce human disease-...
Researchers: Robert Reenan, PhD