The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 32)
Development of an MRI-based Imaging Biomarker for the Detection of Alpha-Synuclein in Parkinson's disease
Parkinson's disease is associated with accumulation of the protein α-synuclein in the brain, however, it is not currently possible to detect α-synuclein in the brain of Parkinson's disease patients. This project is aimed at developing a biomarker for the detection of α-synuclein, which will provide early non-invasive diagnosis of Parkinson's disease and would greatly improve t...
Researchers: Eitan Okun, PhD
Patients with Parkinson's disease (PD) are at a 5.9 times greater risk of developing dementia than the normal population. The identification of sensitive molecular and cellular biomarkers for the cognitive decline in PD patients will facilitate the earlier and more accurate diagnosis of cognitive impairment, identifying disease mechanisms, and novel targets for therapies. The...
Researchers: Lih Fen Lue, PhD
Biomarkers are needed for assisting with the diagnosis of Parkinson's disease (PD) and for monitoring its progression. To date, the most consistent observations pertain to decreased levels of α-synuclein and DJ-1 in the cerebrospinal fluid (CSF) of PD patients. However, obtaining CSF samples is not practical in most cases; therefore, in this proposal, we wish to investigate t...
Researchers: Jing Zhang, MD, PhD
The goal of this research project is to develop and validate a blood test that would identify individuals at risk for developing Parkinson’s disease and at a point in time prior to onset of any of the typical parkinsonian motor symptoms.
This blood test examines protein levels of a key antioxidant response gene, glutathione S-transferase pi, at baseline ...
Researchers: Richard Jay Smeyne, PhD
A biochemical biomarker is a chemical in bodily fluids (e.g. blood, cerebrospinal fluid, urine, etc.) that may be helpful in detecting Parkinson’s disease (PD) or in measuring the progression of PD. Several biochemical biomarkers have been identified in previous studies but the methods to detect these markers utilized crude techniques and the sensitivity must be improved if t...
Researchers: Research Staff of The Michael J. Fox Foundation,