The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 10)
Health and longevity of brain cells depends on the efficiency of their waste removal process, known as autophagy or self-eating. Cells use autophagy to get rid of unwanted protein clumps and broken mitochondria -- cell's energy generators -- among other waste. Accumulation of damaged mitochondria and protein clumps inside the cell are a hallmark of neurodegenerative diseases, such...
Researchers: Erika L.F. Holzbaur, PhD
Supplement to 'Discovery of mGluR4 Potentiators for Symptoms & Side Effects and Disease-Modifying Treatment of PD'
Promising Outcomes of Original Grant:
Activation or potentiation of metabotropic glutamate receptor 4 (mGluR4) is a promising new strategy for both Symptoms & Side Effects and disease-modifying treatment in Parkinson’s disease (PD). Our team has now developed new small molecule drug candidates for mGluR4 which are orally active in pre-clinical models of Parkinson’s disease and possess the balanced...
Researchers: P. Jeffrey Conn, PhD
Surgical approaches to treatment of Parkinson’s disease using deep brain stimulation and corrective lesions provide valuable insights into novel approaches for treatment of this disorder by altering activity in brain circuits that control motor function. This program seeks to develop a novel drug therapy for PD that provides sustained Symptoms & Side Effects relief by inducin...
Clinical, genetic and experimental evidence supports an association between alpha-synuclein expression and Parkinson's disease. This toxicity is likely to be attenuated by strategies that result in a decrease in alpha-synuclein levels. We will develop 'small interfering RNA' (siRNA)-based therapeutics to lower alpha-synuclein expression with the ultimate goal of identifying m...
The Phase III trial is currently recruiting. Learn more: https://foxtrialfinder.michaeljfox.org/trial/4305/
Urate - a natural metabolite and major antioxidant in humans - is emerging as a predictor of both the risk and the progression of typical Parkinson's disease (PD). Studies of healthy individuals have linked urate levels in the upper normal range to a reduced risk of de...