The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 9)
Supplement to 'Discovery of mGluR4 Potentiators for Symptoms & Side Effects and Disease-Modifying Treatment of PD'
Promising Outcomes of Original Grant:
Activation or potentiation of metabotropic glutamate receptor 4 (mGluR4) is a promising new strategy for both Symptoms & Side Effects and disease-modifying treatment in Parkinson’s disease (PD). Our team has now developed new small molecule drug candidates for mGluR4 which are orally active in pre-clinical models of Parkinson’s disease and possess the balanced...
Researchers: P. Jeffrey Conn, PhD
Surgical approaches to treatment of Parkinson’s disease using deep brain stimulation and corrective lesions provide valuable insights into novel approaches for treatment of this disorder by altering activity in brain circuits that control motor function. This program seeks to develop a novel drug therapy for PD that provides sustained Symptoms & Side Effects relief by inducin...
Clinical, genetic and experimental evidence supports an association between alpha-synuclein expression and Parkinson's disease. This toxicity is likely to be attenuated by strategies that result in a decrease in alpha-synuclein levels. We will develop 'small interfering RNA' (siRNA)-based therapeutics to lower alpha-synuclein expression with the ultimate goal of identifying m...
The Phase III trial is currently recruiting. Learn more: https://foxtrialfinder.michaeljfox.org/trial/4305/
Urate - a natural metabolite and major antioxidant in humans - is emerging as a predictor of both the risk and the progression of typical Parkinson's disease (PD). Studies of healthy individuals have linked urate levels in the upper normal range to a reduced risk of de...
Gene therapy holds tremendous potential for the treatment of Parkinson's disease. By using a virus or other DNA delivery system to permanently insert a new gene into critical regions of a Parkinson patient's brain, it is possible to conceive of novel therapies whereby expression of the new gene may improve patients' response to medication, halt the progression of disease, or even reverse pre-exist...