The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 4)
Research Grant, 2013
Promising Outcomes of Original Grant:
One of the objectives of the original study was the development of biochemical and cell-based assays for measuring ATP13A2 protein activity. We largely achieved this goal, which represents an important milestone for the study of ATP13A2. The biochemical assay now allows us, for the first time, to characterize the enzyme properties of ATP13A2 and disease. This m...
Target Validation, 2012
Alpha-synuclein plays a prominent role in Parkinson's disease and identifying valid targets to ameliorate the neurodegenerative effects of alpha-synuclein is a major therapeutic endeavor. ATP13a2 / PARK9 is a strong candidate for a PD therapeutic target as a dose sensitive modifier of alpha-synuclein induced neurodegeneration. Mutations in ATP13a2 result in a juvenile onset ...
Target Validation, 2011
Evaluation of ATP13A2 as a Molecular Target for Ameliorating Alpha-Synuclein-Induced Neurodegeneration in Pre-clinical Models of PD
Mutations in the alpha-synuclein gene cause autosomal dominant Parkinson's disease. While mutant forms of alpha-synuclein are toxic when introduced into neurons and pre-clinical brains, reasons for this are unclear. Recessive mutations in the ATP13A2 gene cause familial parkinsonism, and expression of non-mutated ATP13A2 was recently shown to protect against alpha-synuclein-i...
Researchers: Darren J. Moore, PhD
Rapid Response Innovation Awards, 2011
Mutations in the ATP13A2 gene lead to the Kufor-Rakeb syndrome, a severe early-onset form of Parkinson's disease (PD) with dementia. The ATP13A2 protein is targeted to cellular structures known as lysosomes and belongs to the family of P-type ATPases. All known members of this family are transporters, performing energy-dependent translocations of a specific substrate within t...