The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 68)
Access to Data and Biospecimens, 2018
Uric acid is a chemical produced naturally in the human body. In this project, we aim to investigate whether uric acid is an antioxidant capable of reducing the risk of Parkinson's disease (PD), and in particular, its inherited form caused by a change -- mutation -- in the gene for leucine-rich repeat kinase 2 (LRRK2), the greatest known genetic contributor to PD. In this study...
Researchers: Rachit Bakshi, PhD
Mitochondrial Biomarkers, 2018
Searching for Signs of Mitochondrial Breakdown in People with Parkinson's Disease with an Unknown Cause
Some inherited forms of Parkinson's disease (PD) are caused by mutations (genetic changes) that lead to the breakdown of mitochondria, cell's energy generators. In some cases of sporadic PD -- disease that is not inherited -- mitochondrial breakdown might still be an underlying cause. Little is known about these cases because mutations have been the primary focus of research so fa...
Researchers: Julia Catherine Fitzgerald, PhD
Target Advancement Program, 2016
Cellular senescence (deterioration) is a critical factor of biological aging that occurs in almost all peripheral tissues but little is known about its role in age-related neurodegenerative disorders, such as Parkinson's disease (PD). Senescence occurs in dividing cell types and halts cell proliferation (growth) in an irreversible manner. This process ...
Researchers: Julie K. Andersen, PhD
Target Validation, 2015
Because of its unknown etiology and its link to aging, Parkinson's disease is often seen as a stochastic and pathological acceleration of aging. Using a high-content screening we recently identified an evolutionary conserved pathway that is a key regulator of aging. Further investigation revealed that this pathway is able to protect nigral dopamine neurons in vario...
Researchers: Mickael Decressac, PhD
Rapid Response Innovation Awards, 2014
Although the causes of Parkinson's disease (PD) are yet unknown, the overall health of the body likely plays a major role in disease initiation and progression. However, maintenance and/or restoration of normal systemic activity have been largely overlooked by current pharmaceutical treatments — an approach that has led to a scarcity of effective disease-modifying ...