The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 84)
Therapeutic Pipeline Program, 2017
Alternative Brain Stimulation Approach for the Treatment of Swallowing Impairment in Parkinson's Disease
Dysphagia -- difficulty swallowing -- is common in people with advanced Parkinson's disease (PD). Dysphagia often leads to aspiration -- inhaling of food -- which can result in pneumonia, a leading cause of death in people with advanced PD. These complications substantially worsen health-related quality of life, aggravate the disease and lead to death. Standard treatments, such as ...
Researchers: Daniel Weiss, MD
Improved Biomarkers and Clinical Outcome Measures, 2016
There is a great need to identify Parkinson's disease (PD) in its earliest stages when interventions may prevent or slow neural degeneration. Given that the earliest brain pathology of PD occurs outside of the motor system, namely in the olfactory bulbs (brain regions that detect smell) and the brainstem (brain region that controls involuntary functions), we are probing the functi...
Research Grant, 2016
One of the hallmarks of Parkinson's disease (PD) is the presence and aggregation (clumping) of a misfolded protein called alpha-synuclein; however, we do not know how this misfolding happens. In 2003, Braak and colleagues suggested that alpha-synuclein pathology was "transmissible" (contagious). Additionally, studies have shown that normal dopamine neurons transplanted into Parkins...
Researchers: Richard Jay Smeyne, PhD
Research Grant, 2016
Depression is a common non-motor symptom associated with Parkinson's disease (PD), and impulse control disorders (ICDs) are behaviors that may arise with use of certain PD medications. (Read more about ICDs in Parkinson's.) Both depression and ICDs can significantly affect the quality of life for people with PD and their care partners. It is unknown what changes in the brain cause...
Therapeutic Pipeline Program, 2015
Gait and balance disorders are the primary motor disability in advanced Parkinson's disease (PD). These disorders arise in part due to dysfunction of the lateral mesencephalus [part of the brainstem] and one of its nuclei, the pedunculopontine nucleus (PPN). Deep brain stimulation (DBS) of the PPN area has been used to alleviate gait disorders, and while the init...