The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 88)
Improved Biomarkers and Clinical Outcome Measures, 2018
Does the Brain's Ability to Compensate for the Shortage of Dopamine Affect Parkinson's Disease Progression?
Parkinson's disease (PD) is a progressive disorder, but it is unclear what causes the gradual worsening of the symptoms over the years. It is also unknown why in some cases the disease progresses very rapidly while in others it has a mild course. Here we aim to investigate which brain mechanisms are involved in the gradual worsening of motor symptoms in PD. More specifically, we ai...
Researchers: Rick C.G. Helmich, MD, PhD
Research Grant, 2018
Deep brain stimulation (DBS) is a surgical therapy that delivers small electrical pulses to the brain to decrease movement symptoms of Parkinson's disease (PD). Registry for the Advancement of Deep Brain Stimulation Therapy in Parkinson's Disease (RAD-PD) has the potential to answer clinical questions about deep brain stimulation therapy (DBS) that traditional clinical trials canno...
Researchers: Joohi Jimenez-Shahed, MD
Target Advancement Program, 2018
The two main types of the enzyme 5α-reductase (5αR) play a key role in the production of steroids in the brain and other organs. In pre-clinical testing, we found that inhibitors of both major types of this enzyme prevent damage to brain cells that occur in Parkinson's disease and reduce the severity of dyskinesias. Dyskinesias are one of the major complications of standard treatm...
Researchers: Marco Bortolato, MD, PhD
Therapeutic Pipeline Program, 2017
Alternative Brain Stimulation Approach for the Treatment of Swallowing Impairment in Parkinson's Disease
Dysphagia -- difficulty swallowing -- is common in people with advanced Parkinson's disease (PD). Dysphagia often leads to aspiration -- inhaling of food -- which can result in pneumonia, a leading cause of death in people with advanced PD. These complications substantially worsen health-related quality of life, aggravate the disease and lead to death. Standard treatments, such as ...
Researchers: Daniel Weiss, MD
Improved Biomarkers and Clinical Outcome Measures, 2016
There is a great need to identify Parkinson's disease (PD) in its earliest stages when interventions may prevent or slow neural degeneration. Given that the earliest brain pathology of PD occurs outside of the motor system, namely in the olfactory bulbs (brain regions that detect smell) and the brainstem (brain region that controls involuntary functions), we are probing the functi...