The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 5)
Therapeutic Pipeline Program, 2018
Many people with Parkinson's disease (PD) have an abnormal glucocerebrosidase (GBA) enzyme, which causes them to accumulate fatty acids -- chemicals that make up fat -- in the brain and other organs. The exact relationship between Parkinson's and GBA abnormalities is unclear. Recent research findings suggest that replacing the abnormal, dysfunctional GBA with its functional form de...
Researchers: Jennyfer Bultinck, PhD
Research Grant, 2013
Promising Outcomes of Original Grant:
The molecular events that precipitate the onset of Parkinson's disease (PD) have yet to be precisely defined; however current research indicates that the Leucine Rich Repeat Kinase 2 (LRRK2) protein plays a central role in the disease. LRRK2 is a cellular signaling protein, in other words it's a protein involved in fine tuning how cells run by turning cellular ...
Exactly how Parkinson’s disease (PD) develops is not known, however current research indicates that the leucine rich repeat kinase 2 (LRRK2) protein plays a central role in the disease. LRRK2 is a cellular signaling protein, in other words it’s a protein involved in fine tuning how cells run by turning cellular processes on and off. Finding out what flips LRRK2’s on-off switc...
Target Validation, 2010
FK506 Binding Proteins (FKBPs) are enzymes that play a role in protein folding. FKBPs are highly expressed in human brain and are thought to be involved in neurodegenerative disorders, including Parkinson's disease (PD). FKBP inhibitors such as FK506 were shown to be protective in different models of brain injury and neurodegeneration, but the precise mechanism is not well un...
Postural Instability and Gait Disturbances, 2009
Role of the Posterior Parietal Cortex and Pedunculopontine Nucleus in the Pathophysiology of Freezing of Gait: An MRI and TMS Study
Although disturbances in the posterior parietal cortex (PPC) and pedunculopontine nucleus (PPN) are thought to be involved in the development of freezing of gait (FOG) in PD patients, their respective roles remain poorly understood. Here, we will use brain magnetic resonance imaging (MRI) to investigate how these key brain regions interact with other areas when they are engag...
Researchers: Julien Crémers, MD