The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 67)
Therapeutic Pipeline Program, 2017
The goal of this project is to find therapeutic drugs for Parkinson's disease (PD) that target alpha-synuclein, a key player in PD. We propose that the negative impact of alpha-synuclein on called vesicles (storage packets) and the block of cell functions, including debris removal (phagocytosis) and nerve signaling, leads to disease progression. We are developing therapeutic comp...
Researchers: Lisa Claire McConlogue, PhD
PPMI Data Challenge, 2016
Multivariate Prediction of Parkinson's Disease Clinical Progression (2016 PPMI Data Challenge Winner)
Parkinson's disease (PD) is heterogeneous in both clinical representation and prognosis, as indicated by a large diversity of rates of progression in motor as well as non-motor symptoms. It could therefore be helpful to have well-characterized and distinct subtypes of Parkinson's disease slow and fast clinical progression and have early indicators of the clinical progression rate f...
Researchers: Duygu Tosun-Turgut, PhD
Target Validation Pilot Award, 2016
Rare mutations in the PINK1 gene cause familial (inherited) Parkinson's disease (PD). However, it is not known if PINK1 contributes to the development of idiopathic (no known cause) PD. Studies on the function of PINK1 suggest that it plays a role in the breakdown of damaged mitochondria, the energy factories of cells, through a process known as autophagy. Emerging evidence indicat...
Researchers: Garrett Geoffrey Gross, PhD
Research Grant, 2016
Epigenetic processes (changes in gene expression), such as DNA methylation (mechanism that cells use to control gene expression), ensure proper functioning of genetic materials in cells. Our previous studies found abnormal DNA methylation in blood samples from individuals with Parkinson's disease (PD). These changes may be associated with the disease and may also serve as potentia...
Research Grant, 2016
A substantial proportion of individuals with Parkinson's disease develop cognitive
impairment, or difficulty with thinking abilities. The basis for these changes is poorly
understood. We now can image the deposition of two abnormal proteins that accumulate in the brains of older individuals. These proteins, beta-amyloid and tau, can be imaged using positron emitting tomography (a typ...