The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 28)
Research Grant, 2016
GBA Meta-analysis Initiative: Charting a Path to Success for Clinical Trials in Patients with GBA-PD
Promising Outcomes of Original Grant:
We ascertained the associations between GBA mutations and cognitive and motor outcomes in seven large cohorts representing 2,304 patients with PD (including 221 carrying a GBA mutation) and 20,868 longitudinal study visits conducted in England, the Netherlands, France, Canada and the United States. This study found that GBA mutations hasten the longitudinal pro...
Research Grant, 2016
Defining Structural Forms of Alpha-synuclein Responsible for Key Features Associated with Parkinson's Disease
The alpha-synuclein pre-formed fibril (PFF) model shows promise for modeling many features of Parkinson's disease (PD). In this model, PFFs induce pathological features and behaviors that closely resemble those found in PD. The PFFs consist of a mixture of different structural forms of alpha-synuclein and it is not known which form is responsible for PD.
We will develo...
LRRK2 Role in Idiopathic Parkinson's Disease, 2014
Genetic variability in the LRRK2 gene is recognized as one of the most common cause of Parkinson's disease (PD) mainly in the Caucasian, African-Arab, Ashkenazi Jewish and East Asian populations. There is a complete lack of knowledge regarding the role of LRRK2-dependent PD in the Indian population. To understand the role of the LRRK2 locus and its prevalence in the Indian popu...
Rapid Response Innovation Awards, 2014
We recently reported a new, practical approach to rate segmental progression of cardinal motor symptoms in Parkinson's disease (PD) at early stages. We computed four new scores — the Bradykinesia Segmental Score, the Tremor Segmental Score, the Rigidity Segmental Score and the Combined Segmental Score —evaluating the anatomical spread of the cardinal motor symptoms of PD on th...
Improved Neuromodulation Approaches, 2014
Deep brain stimulation (DBS) is an effective treatment for many patients with advanced stage Parkinson's disease (PD) when symptoms are not adequately controlled with medication. Vanderbilt University recently completed a U.S. Food and Drug Administration (FDA)-approved pilot clinical trial of safety and tolerability of DBS in early-stage PD. Based on the results of the pilot, the ...
Researchers: Philip David Charles, MD