The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 36)
Research Grant, 2016
The LRRK2 gene has been implicated in Parkinson's disease, but is too large to be expressed in viral vectors, a tool to modify cells. In order to study LRRK2 function, one needs a viral vector that permits expression of LRRK2. Helper dependent adenovirus (HdAd) can package large genes and so are an ideal viral vector system for LRRK2 expression.
Target Optimization Awards, 2016
Mitochondria, cellular power plants, malfunction in Parkinson's disease (PD) and with advanced age. Aging and PD cause changes in communication between mitochondria and the rest of the cell, which prevents the elimination and replacement of malfunctioning mitochondria. Blocking faulty avenues of communication can preserve mitochondria function and slow PD progression.
Researchers: Jeremy W. Chambers, PhD
Target Validation Pilot Award, 2016
Abnormal build-up of the protein alpha-synuclein in Parkinson's disease (PD) has been linked to cell stress and death. These deficits can be rescued by expressing certain proteins that affect endoplasmic reticulum-golgi (production and sorting of proteins and lipids) trafficking (movement across the cell). Increasing evidence suggests that the Retention in endoplasmic reticulum 1 ...
Researchers: Nikolaus McFarland, MD, PhD
LRRK2 Challenge, 2016
Genetic studies looking at differences in DNA have identified key genes that can cause Parkinson's disease (PD) in families and contribute to the overall risk of developing sporadic disease. The most common genetic cause of both inherited and sporadic disease is a specific change in a gene called Leucine-Rich Repeat Kinase 2 (LRRK2). Through our work and others, a portion of the L...
Rapid Response Innovation Awards, 2014
Aggregation of the protein alpha-synuclein and dysfunction of mitochondria (the powerhouse of the cell) are two critical components of Parkinson's disease. We have recently found that the protein Pum2 can regulate alpha-synuclein protein synthesis at the vicinity of mitochondria. Interestingly, molecules called reactive oxygen species (ROS) made by mitochondria ind...
Researchers: Yoon-Seong Kim, MD, PhD