The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 85)
Target Validation Award, 2017
Mitochondria provide energy for neurons to function and survive. Evidence suggests that individuals with Parkinson's disease (PD) have poorly functioning mitochondria, such that the energy demand is not met and toxic products build up and cause damage to neurons. USP30 is a newly discovered protein that regulates the clearance of poorly functioning mitochondria by modifying levels...
Researchers: Paul Thompson, PhD
Research Grant, 2017
Healthy mitochondria (powerhouses of the cell) are crucial to the survival of neurons, and poorly-functioning mitochondria are implicated in the neurodegeneration associated with Parkinson's disease (PD). The maintenance of a healthy population of mitochondria in a neuron requires the synthesis of new mitochondria, their transport to the many parts of the cell where they are neede...
Researchers: Thomas L. Schwarz, PhD
Research Grant, 2017
Mitochondrial dysfunction (powerhouse of the cell), free-radical induced injury (highly reactive atoms that can be harmful) and inflammatory mechanisms have been proposed to play a key role in the neurodegenerative processes of Parkinson's disease (PD). Mitochon Pharmaceuticals has demonstrated that a once-a-day oral treatment with MP101, a brain-penetrant mitochondrial modulator,...
Researchers: John Gerard Geisler, PhD
Therapeutic Pipeline Program, 2016
Mitochondrial dysfunction has a prominent role in the process of Parkinson's disease (PD). Mutations in at least seven genes are known to underlie PD, most of them encode proteins that impact mitochondrial function and clearance, cellular oxidative stress or redox balance. This project aims to repurpose KH176, a molecule currently under development for the treatment of mitochondria...
Researchers: Johannes Albertus Maria Smeitink, MD, PhD
Target Validation, 2016
Targeting the Lysosomal Pathway to Ease Mitochondrial Dysfunction in IPSC-Derived Neurons from People with Parkinson's and GBA Mutations
Mutations of the GBA gene, which encodes the enzyme glucocerebrosidase (GCase), are associated with Parkinson's, and we have recently shown that loss of GCase activity gives rise to impaired mitochondrial function, itself associated with Parkinson's. We propose that impaired clearance of damaged mitochondria by a process called autophagy (which is dysfunctional in people with GBA m...
Researchers: Michael R. Duchen, BA (Oxon), MBBS, FRC