The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 5)
Research Grant, 2016
GBA Meta-analysis Initiative: Charting a Path to Success for Clinical Trials in Patients with GBA-PD
Promising Outcomes of Original Grant:
We ascertained the associations between GBA mutations and cognitive and motor outcomes in seven large cohorts representing 2,304 patients with PD (including 221 carrying a GBA mutation) and 20,868 longitudinal study visits conducted in England, the Netherlands, France, Canada and the United States. This study found that GBA mutations hasten the longitudinal pro...
Therapeutic Pipeline Program, 2014
Tryptophan-2,3-dioxygenase (TDO) is a key enzyme in the tryptophan degradation pathway. In a Parkinson's disease (PD) model, TDO was identified as a potential therapeutic target. Scientists at the Netherlands Translational Research Center (NTRC) have developed an innovative TDO screening assay (laboratory experiment) and have applied this assay to identify inhibi...
Researchers: Rogier C. Buijsman, PhD
Rapid Response Innovation Awards, 2013
The neural network of the gut called the enteric nervous system (ENS) is affected by the pathological process in PD. One of the relevant features of the ENS is its accessibility to biopsies, making it a putative original source of biomarkers for PD. The ENS does not only contain neurons but also enteric glial cells (EGC), the counterpart of the brain astrocytes. The aim of our...
Defining Cognitive Phenotypes of Parkinsonâ€™s Disease, 2011
Cognitive impairment with and without dementia is frequent in Parkinson's disease (PD). However, there is a high heterogeneity in the clinical presentation of these cognitive deficits. We assume that a data-driven approach may overcome this issue and help define specific cognitive presentations of PD patients.
The objective of this study is to identify different clinical pres...
Researchers: Kathy Dujardin, PhD
Clinical Intervention Awards, 2007
The PARKFIT Study: Effectiveness of an Active Lifestyle Promotion Program for Patients with Parkinson's disease
Parkinson's patients are inclined toward a sedentary lifestyle. This is due to a combination of both physical handicaps (e.g. walking difficulties) and mential impairments (e.g. depression). Improving the amount of physical activity in PD is probably beneficial for many reasons. First, this would reduce the number of disease complications, such as cardiovascular disease or di...