The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 134)
Research Grant, 2019
Chronic inflammation of immune cells our brains is now believed to be associated with the onset and progression of Parkinson's disease. These cells produce a target in Parkinson's patients called the NLRP3 inflammasome, which is validated as a key driver of neuroinflammation. Inflazome has developed a clinical candidate drug that blocks this target and that may stop the chronic cy...
Research Grant, 2019
The goal of this study is to develop an imaging tool (a radiotracer) that could be used to show the protein alpha-synuclein in the brains of living people with a brain scan call a positron emission tomography (PET) scan. Alpha-synuclein clumps in the cells of people with Parkinson's and other brain diseases called synucleinopathies, which include Lewy body dementia and multiple sy...
Researchers: Robert H. Mach, PhD
Research Grant, 2018
There is a pressing need for Parkinson's disease (PD) biomarkers -- objective measures of disease -- that will enable early and accurate diagnosis and allow to track disease progression and therapeutic improvement. We have developed a new mathematical method to characterize PD-related brain networks. This method is based on a mathematical analysis of data collected via resting sta...
Biomarkers Across Neurodegenerative Diseases, 2018
This study builds on two recent discoveries in neuroscience: first, the brain is organized in large-scale networks of nerve cells; and second, the clumps of alpha-synuclein, amyloid and tau -- proteins implicated in Parkinson's disease (PD) and Alzheimer's disease (AD) -- can spread from nerve cell to nerve cell, like infection.
Parkinson's and Alzheimer's affect diffe...
Researchers: Alain Dagher, MD
Improved Biomarkers and Clinical Outcome Measures, 2018
Does the Brain's Ability to Compensate for the Shortage of Dopamine Affect Parkinson's Disease Progression?
Parkinson's disease (PD) is a progressive disorder, but it is unclear what causes the gradual worsening of the symptoms over the years. It is also unknown why in some cases the disease progresses very rapidly while in others it has a mild course. Here we aim to investigate which brain mechanisms are involved in the gradual worsening of motor symptoms in PD. More specifically, we ai...
Researchers: Rick C.G. Helmich, MD, PhD