The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 124)
Research Grant, 2018
There is a pressing need for Parkinson's disease (PD) biomarkers -- objective measures of disease -- that will enable early and accurate diagnosis and allow to track disease progression and therapeutic improvement. We have developed a new mathematical method to characterize PD-related brain networks. This method is based on a mathematical analysis of data collected via resting sta...
Biomarkers Across Neurodegenerative Diseases, 2018
This study builds on two recent discoveries in neuroscience: first, the brain is organized in large-scale networks of nerve cells; and second, the clumps of alpha-synuclein, amyloid and tau -- proteins implicated in Parkinson's disease (PD) and Alzheimer's disease (AD) -- can spread from nerve cell to nerve cell, like infection.
Parkinson's and Alzheimer's affect diffe...
Researchers: Alain Dagher, MD
Improved Biomarkers and Clinical Outcome Measures, 2018
Does the Brain's Ability to Compensate for the Shortage of Dopamine Affect Parkinson's Disease Progression?
Parkinson's disease (PD) is a progressive disorder, but it is unclear what causes the gradual worsening of the symptoms over the years. It is also unknown why in some cases the disease progresses very rapidly while in others it has a mild course. Here we aim to investigate which brain mechanisms are involved in the gradual worsening of motor symptoms in PD. More specifically, we ai...
Researchers: Rick C.G. Helmich, MD, PhD
Inflammation Biomarkers Program, 2018
While immune cells protect us from infection, they can also cause damage by inadvertently responding to other, non-infectious events. Such immune response occurs in Parkinson's disease (PD) and likely contributes to disease progression through promoting inflammation in the brain. As we age, the immune system becomes more "experienced," that is, effective in fighting infections enco...
Research Grant, 2018
A synapse is a structure that allow nerve cells (i.e., neurons) to communicate with one-another or with target cells. Changes in synaptic density are associated with a variety of brain disorders and psychiatric diseases, including Parkinson's and Alzheimer's. An imaging agent that detects synaptic changes could be used to diagnose brain diseases and determine patient response to t...