The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 10)
Research Grant, 2018
There is a pressing need for Parkinson's disease (PD) biomarkers -- objective measures of disease -- that will enable early and accurate diagnosis and allow to track disease progression and therapeutic improvement. We have developed a new mathematical method to characterize PD-related brain networks. This method is based on a mathematical analysis of data collected via resting sta...
Access to Data and Biospecimens, 2018
Uric acid is a chemical produced naturally in the human body. In this project, we aim to investigate whether uric acid is an antioxidant capable of reducing the risk of Parkinson's disease (PD), and in particular, its inherited form caused by a change -- mutation -- in the gene for leucine-rich repeat kinase 2 (LRRK2), the greatest known genetic contributor to PD. In this study...
Researchers: Rachit Bakshi, PhD
Biomarkers Across Neurodegenerative Diseases, 2018
This study builds on two recent discoveries in neuroscience: first, the brain is organized in large-scale networks of nerve cells; and second, the clumps of alpha-synuclein, amyloid and tau -- proteins implicated in Parkinson's disease (PD) and Alzheimer's disease (AD) -- can spread from nerve cell to nerve cell, like infection.
Parkinson's and Alzheimer's affect diffe...
Researchers: Alain Dagher, MD
Research Grant, 2017
Drawing on the Parkinson's Progression Markers Initiative (PPMI) Data to Link Changes in the PINK1/Parkin Genes with Parkinson's Disease
Two proteins, PINK1 and Parkin, prevent cell death by breaking down damaged mitochondria, cell's energy generators. This process is known as mitophagy. Mutations in PINK1/Parkin genes -- genetic changes that render these proteins unable to perform their function -- cause Parkinson's disease (PD). Failure to remove damaged mitochondria from the cell can start or speed up the course...
Computational Science, 2017
Analyzing Data from the Parkinson's Progression Markers Initiative to Identify Subtypes of Parkinson's Disease
Parkinson's disease (PD) presents and progresses variably, so no two people with Parkinson's have the same disease. The diversity of PD clinical manifestations makes the disease more challenging to diagnose and treat. The goal of this project is to discover Parkinson's subtypes -- patterns of disease progression -- by analyzing clinical, neuroimaging and genetic information from p...
Researchers: Fei Wang, PhD