The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 583)
LRRK2 Biology Consortium, 2018
Parkinson's disease (PD) affects nearly any body system, as evidenced by the diversity of its symptoms. While its non-motor symptoms, such as olfactory dysfunction, rapid eye movement sleep behavior disorder (RBD) and gastrointestinal (GI) abnormalities, do not define the disease, they have a large impact on those living with it. In this project, we will use a pre-clinical model o...
Researchers: R. Jeremy Nichols, PhD
Research Grant, 2018
Using pre-clinical models of Parkinson' disease (PD), we found CD163-positive macrophages -- immune cells with the CD163 protein on their surface -- to play an active role in neurodegeneration. We also found that in human samples CD163 is modified as a result of PD-related processes in the nervous system. Furthermore, these changes in CD163 correlated with PD symptoms. Together, t...
Researchers: Marina Romero-Ramos, PhD
Research Grant, 2018
In the past, we demonstrated that using drugs to deactivate Rho-associated protein kinase (ROCK), a protein regulating shape and movement of cells, can protect dopamine-producing brain cells from damage caused by alpha-synuclein, a sticky protein that clumps in the brains of people with Parkinson's disease (PD). However, the optimal drug for ROCK deactivation in PD has not yet bee...
Target Advancement Program, 2017
Toll-like Receptor Inhibition to Block Alpha-synuclein-induced Pro-inflammatory Signaling and Cytokine Release
Synucleinopathies, including Parkinson's disease (PD), are a family of central nervous system (CNS) degenerative disorders characterized by alpha-synuclein protein-containing aggregates. Toll-like receptors (TLRs), which includes TLR2, play a critical role in the immune system's response to foreign pathogens that can trigger adverse inflammatory signaling. Recently, alpha-synuclein...
Researchers: Martin B. Gill, PhD
Therapeutic Pipeline Program, 2017
Addex Pharmaceuticals has developed drug discovery tools that can be used to screen its small molecule compound library for positive allosteric modulators (protein regulators) of TrkB, a neuroprotective receptor. We have screened several independent chemical series of a type of chemical compounds, called TrkB PAMs, which can become optimized (improved) to become potential Parkinso...
Researchers: Robert Lutjens, PhD