The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 54)
LRRK2 Biology Consortium, 2017
Promising Outcomes of Original Grant:
Our original project investigated how the LRRK2 mutation, the principal genetic cause of Parkinson's disease (PD), alters brain activity involved in movement control and sleep quality. In line with our original hypothesis, we observed that pre-clinical models with the LRRK2 mutation slept less and had more powerful sleep spindles, a form of brain wave involved ...
Researchers: Stephen L. Cowen, PhD
Target Advancement Awards, 2017
The pathological hallmark of Parkinson's disease (PD) is the widespread accumulation of cellular deposits (Lewy Bodies) comprised of clumps of a misfolded protein called alpha-synuclein. Evidence suggests that misfolded alpha-synuclein can be taken up into healthy neurons where it seeds further clumping of toxic alpha-synuclein. Prevention of the uptake of pathological alpha-synuc...
Researchers: Caryl E. Sortwell, PhD
Research Grant, 2017
Dystonia and Parkinson's disease (PD) are closely related movement disorders. Dystonia is characterized by painful, prolonged muscle contractions that cause involuntary, repetitive twisting and sustained muscle contractions. Some experts estimate that 40 percent of people with PD experience dystonia as an early symptom or complication of treatment. Deep brain stimulation (DBS) is ...
Researchers: Harrison C. Walker, MD
Therapeutic Pipeline Program, 2017
Alternative Brain Stimulation Approach for the Treatment of Swallowing Impairment in Parkinson's Disease
Dysphagia -- difficulty swallowing -- is common in people with advanced Parkinson's disease (PD). Dysphagia often leads to aspiration -- inhaling of food -- which can result in pneumonia, a leading cause of death in people with advanced PD. These complications substantially worsen health-related quality of life, aggravate the disease and lead to death. Standard treatments, such as ...
Researchers: Daniel Weiss, MD
Research Grant, 2016
Chronic Effects of Low Frequency Deep Brain Stimulation on Aspiration, Freezing of Gait and Other Axial and Motor Symptoms in Parkinson's Disease
Our recent study (Xie et al., Neurology. 2015;84:415-420) found that 60Hz stimulation, compared to the traditional 130Hz, decreased aspiration frequency and swallowing difficulty, medication refractory freezing of gait (FOG), and other axial symptoms and parkinsonism in those with Parkinson's disease (PD) following bilateral subthalamic nuclei (brain regions associated with PD; STN...
Researchers: Tao Xie, MD, PhD