The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 56)
Research Grant, 2018
Deep brain stimulation (DBS) is a surgical therapy that delivers small electrical pulses to the brain to decrease movement symptoms of Parkinson's disease (PD). Registry for the Advancement of Deep Brain Stimulation Therapy in Parkinson's Disease (RAD-PD) has the potential to answer clinical questions about deep brain stimulation therapy (DBS) that traditional clinical trials canno...
Researchers: Joohi Jimenez-Shahed, MD
Research Grant, 2018
Cell replacement using induced pluripotent stem cells (iPSCs) is a potential restorative therapy for Parkinson's disease. Replacing brain cells that produce dopamine, a chemical affected in Parkinson's, could address both motor symptoms, as well as L-dopa-induced dyskinesias. The team, with previous MJFF funding, has completed pre-clinical dose-escalation studies demonstrating lon...
LRRK2 Biology Consortium, 2017
Promising Outcomes of Original Grant:
Our original project investigated how the LRRK2 mutation, the principal genetic cause of Parkinson's disease (PD), alters brain activity involved in movement control and sleep quality. In line with our original hypothesis, we observed that pre-clinical models with the LRRK2 mutation slept less and had more powerful sleep spindles, a form of brain wave involved ...
Researchers: Stephen L. Cowen, PhD
Target Advancement Program, 2017
The pathological hallmark of Parkinson's disease (PD) is the widespread accumulation of cellular deposits (Lewy Bodies) comprised of clumps of a misfolded protein called alpha-synuclein. Evidence suggests that misfolded alpha-synuclein can be taken up into healthy neurons where it seeds further clumping of toxic alpha-synuclein. Prevention of the uptake of pathological alpha-synuc...
Researchers: Caryl E. Sortwell, PhD
Research Grant, 2017
Dystonia and Parkinson's disease (PD) are closely related movement disorders. Dystonia is characterized by painful, prolonged muscle contractions that cause involuntary, repetitive twisting and sustained muscle contractions. Some experts estimate that 40 percent of people with PD experience dystonia as an early symptom or complication of treatment. Deep brain stimulation (DBS) is ...
Researchers: Harrison C. Walker, MD