The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 24)
Therapeutic Pipeline Program, 2018
There are no therapies that slow down the loss of brain cells affected by Parkinson's disease. Prior research suggests that dual leucine zipper kinase (DLK) regulates stress response in brain cells and contributes to cell degeneration and death. Inhibiting DLK may block this response, keep brain cells from dying, and preserve function in people with Parkinson's disease. This pre-c...
Researchers: Ronald A. DePinho, MD
LRRK2 Biology Consortium, 2017
One of the most common inherited causes of Parkinson's disease (PD) is defect in the LRRK2 protein caused by changes, or mutations, of the LRRK2 gene. Our previous studies have shown that immune cells called macrophages are unable to carry a normal immune response without LRRK2. We now aim to explain how changes in the LRRK2 gene and protein influence immune response in people wit...
Researchers: Robert O. Watson, PhD, MPH
Research Grant, 2014
Parkinson's disease (PD) is associated with the presence of protein aggregates in the form of Lewy bodies composed of the protein alpha-synuclein. One of the greatest obstacles for developing a disease-modifying therapy for PD is the lack of early diagnosis. To date, there is no definite, sensitive and predictive laboratory test available that can identify indivi...
Researchers: Claudio Soto, PhD
Rapid Response Innovation Awards, 2014
Loss of dopaminergic neurons is seen in Parkinson's disease, and transplantation of these neurons can greatly ease symptoms. However, several major drawbacks are associated with transplantation-based therapy, begging for alternatives to treat Parkinson's. Cutting-edge research shows that the fate of cells can be re-engineered in the adult brain, raising the hope of using a patient'...
Rapid Response Innovation Awards, 2013
Evaluation of Targeted Plasticity Therapy as a Treatment for Motor Dysfunction in Parkinson's Disease
Deterioration of motor function is a debilitating symptom of Parkinson's disease (PD). We have recently developed a novel method that utilizes stimulation of the vagus nerve delivered during rehabilitative training to improve motor function after various types of brain injury. Vagus nerve stimulation (VNS) enhances plasticity, or the ability to change, within ne...