The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 70)
Access to Data and Biospecimens, 2018
Uric acid is a chemical produced naturally in the human body. In this project, we aim to investigate whether uric acid is an antioxidant capable of reducing the risk of Parkinson's disease (PD), and in particular, its inherited form caused by a change -- mutation -- in the gene for leucine-rich repeat kinase 2 (LRRK2), the greatest known genetic contributor to PD. In this study...
Researchers: Rachit Bakshi, PhD
Research Grant, 2017
Mutations in the LRRK2 and GBA genes increase the risk for Parkinson's disease (PD). The mechanism by which these mutations increase PD risk is unknown. One potential explanation may be that the activity of the enzymes (chemicals that increase chemical reactions) encoded by these genes is increased (as suspected in LRRK2) or reduced (as suspected in GBA). The purpose of this stud...
LRRK2 Biology Consortium, 2017
Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease
Several genes play a crucial role in Parkinson's disease (PD). The most common genetic cause of PD is mutations in the gene encoding LRRK2, a very large and complex protein with different enzyme (accelerates chemical reactions) functions. Targeting the multiple enzymatic functions of LRRK2 represents a very attractive approach for designing novel therapeutics for PD that requires ...
Target Advancement Program, 2017
Galectins proteins (proteins that bind sugar molecules) mediate the cellular response to endocytic (transfer of molecules to cells) vesicles (storage sacks) ruptured by amyloid proteins (protein clumps), such as alpha-synuclein (sticky protein that accumulates in the brains of those with Parkinson's). We have observed that vesicles containing alpha-synuclein either fuse with simil...
Researchers: Edward M. Campbell, PhD
Research Grant, 2017
Promising Outcomes of Original Grant:
Stem cells are a renewable source of tissue that can be coaxed to become different cell types of the body. When prompted, stem cell models can become neural cells. Previously, we successfully developed several stem cell models by altering skin cells from people with Parkinson's disease (PD). We then gave these stem cells the ability to make precise amounts of a...
Researchers: Birgitt Schüle, MD, Dr. med.