Role of Striatal Cholinergic Interneurons in Parkinsonís Disease Dyskinesia
Research Grant, 2014
Study Rationale: † † † † † † † † ††
In pre-clinical models, we identified an important role of cholinergic interneurons ó which release the neurotransmitter acetylcholine ó from part of the brain called the striatum in levodopa-induced dyskinesia. This small population of striatal neurons has not been well studied and may present a new therapeutic target.
We hypothesize that modulating the activities of striatal cholinergic interneurons can alter dyskinesia.
We will test methods to modulate the effect of cholinergic neuronal activity by expressing genetically modified receptors. We will inhibit the neuronal activity and study if dyskinesia can be prevented or reduced.
Impact on Diagnosis/Treatment of Parkinsonís Disease: † † † † † ††
This study will provide a functional evidence for importance of cholinergic interneurons in dyskinesia treatment. Treatment of Parkinsonís disease has been advanced by pharmacological approaches and modulation of specific areas of the brain using lesions or deep brain stimulation. Cell type-specific modulation could provide the next generation of refined therapeutic approaches.
Next Steps for Development:
Once the functional role of cholinergic interneurons is firmly established, we will explore therapeutic targets that are present in this specific cell type.
H. Houston Merritt Professor of Neurology and Chief of the Movement Disorders Division at Columbia University
Location: New York, New York, United States