Simple Blood Tests for Parkinson's Disease Derived from Genome-wide Expression Changes
MJFF Research Grant, 2004
This grant builds upon the research from a prior grant:
In work from their initial grant, Drs. Steven Gullans and Clemens Scherzer at Brigham and Women’s Hospital identified a number of genes that are differentially expressed in blood cells of patients with idiopathic PD vs. healthy control subjects.
Given these exciting findings, the research team will now validate the differential expression of these genes in blood samples from a larger group of PD patients. Validation is essential in studies of this kind to ensure that any potential biomarker(s) can be useful in a wide subset of the PD patient population.
The researchers will also continue with their goal of developing a relatively simple clinical blood test that would look for specific expression of a single differentially expressed gene or pattern of genes useful for predicting PD risk.
Head of the Neurogenomics Lab and the Parkinson Personalized Medicine Initiative at Harvard and Brigham and Women’s Hospital
Associate Professor of Neurology at Harvard Medical School
Location: Cambridge, Massachusetts, United States