Male transgenic rat Parkinson's disease model characterization
MJFF Research Grant, 2010
Promising Outcomes of Original Grant:
The original project focused on the creation and characterization of pre-clinical models that express mutations in the protein alpha-synuclein that are known to cause human Parkinson’s disease (PD). These models were found to exhibit alterations in behavior and neurotransmitter levels. Such findings warrant a more thorough and detailed investigation of the potential PD phenotype in these models.
Objectives for Supplemental Investigation:
At 12 months of age, pre-clinical models expressing Parkinson’s disease (PD)-causing mutations will be examined for neurochemical and neuropathological alterations, compared to wild-type controls (models not expressing the mutation). This work represents a more detailed examination of these key endpoints compared to the original proposal.
Importance of This Research for the Development of a New PD Therapy:
These models may provide a new genetic model of PD that may be useful for testing potential therapies. Because alpha-synuclein is involved in both genetic and sporadic forms of PD, such animals may be particularly useful in assessing the efficacy of therapeutics targeted at alpha-synuclein. The characterization of these animals in this project is the first major step in determining the utility of these animals for PD research.
Director, Pittsburgh Institute for Neurodegenerative Diseases at University of Pittsburgh
Location: Pittsburgh, Pennsylvania, United States