Motor fluctuations are "off" times, when medication — namely levodopa (the "gold standard" treatment for Parkinson's) — is not working optimally and Parkinson's symptoms (motor and/or non-motor) return. "Off" periods are more common as the disease progresses and people take medication for a longer period of time.
Management options include dietary and medication adjustments and, for some, surgical therapy (such as deep brain stimulation). Additional therapies that may help avoid "off" periods or quickly alleviate them may be available within the next few years; several are in the later stages of the development pipeline. Treatment regimens are, however, unique to each individual and must be decided upon after careful consideration with one's personal physician.
Watch the video to learn more about motor fluctuations.
Find recruiting clinical trials studying therapies for "off" times and other Parkinson's symptoms.
Thank you to our 2016 Parkinson's Disease Education Consortium Supporter and Steering Committee members. While our generous sponsors make our educational offerings possible, their support does not influence MJFF's content, perspective or panelist selection. The "Ask the MD" Video and Blog Series was launched in 2015 with the support of Acorda Therapeutics Inc.