A treatment that could slow or stop Parkinsonís disease today took one step closer to pharmacy shelves. The Austrian biotech AFFiRiS AG announced positive results of its Phase I safety trial of a vaccine against alpha-synuclein.
Alpha-synuclein is the sticky protein that clumps in the cells of people with Parkinsonís, and AFFiRiS hopes to stop disease by inducing antibodies against alpha-synuclein accumulation. The Michael J. Fox Foundation funded this work with close to $2M, first with a grant for a pre-clinical study and then $1.5M in 2011 for the Phase I trial. Itís the first drug against alpha-synuclein to reach clinical testing.
ďA treatment that could slow or stop Parkinsonís progression would be a game changer for the five million worldwide living with this disease and the many more who will become at risk as our population ages,Ē said MJFF CEO Todd Sherer, PhD. ďThis trial is one of the most promising efforts toward that goal.Ē
In two different doses the drug, called PD01A, was safe and tolerable. Half of those vaccinated showed alpha-synuclein antibodies, which is a promising but very early sign. Further trials will test PDO1Aís benefit to patients.
The next step is a boost study that will test the safety and effect of a boost vaccination (another dose). MJFF will support that trial, which will take place in Vienna, Austria and start recruiting in September.
The AFFiRiS trial is one study in the Foundationís robust alpha-synuclein portfolio. Read more about other ways weíre targeting this protein.
Hear more about this study and watch MJFF CEO Todd Sherer, PhD, discuss the potential of an alpha-synuclein therapy at todayís AFFiRiS press conference in New York.