World Pharma Congress - Philadelphia

Mutations in LRRK2 represent the most frequently found genetic factors yet discovered for PD and its role as a putative kinase, combined with the fact that disease-associated mutations appear to enhance this activity, make it is an attractive target for therapeutic development. Given the unanswered questions surrounding basic biological aspects of LRRK2 function, MJFF has endeavored to generate, characterize and distribute those tools, including antibodies, assays, viral vectors and animal models, that will assist investigators in their pursuit of understanding how LRRK2 function is dysregulated in PD.

Authors: Sonal S. Das