Wolfdieter Springer, PhD
Associate Professor of Neuroscience at Mayo Clinic
Location: Jacksonville, Florida, United States
Wolfdieter Springer, PhD, is an associate professor in the Department of Neuroscience and head of the Parkinson's Disease Cell Biology Laboratory at Mayo Clinic in Jacksonville, Florida. Springer received his MSc in biology from the University of Regensburg in Germany in 1999, and earned his doctoral degree in biochemistry from the Ludwig Maximilian University in 2005. For more than 15 years, he has studied the molecular and cellular mechanisms linked to Parkinson's disease (PD) and related disorders. Springer has helped to identify the PINK1/Parkin-directed mitochondrial quality control pathway, which serves to remove damaged mitochondria - energy generators - from the cell. His recent work highlights the relevance of this process, known as mitophagy, as well as the contribution of certain changes in the PINK1 gene to disease. Besides these studies, his laboratory is searching for ways to diagnose and treat diseases that have mitochondrial damage in common.
- Drawing on the Parkinson's Progression Markers Initiative (PPMI) Data to Link Changes in the PINK1/Parkin Genes with Parkinson's Disease (2017)
- Hit-to-Lead Optimization of Parkin Activators through Structure-Function Analyses (2015)
- Identification of Parkin Activators through Structure-Function Analyses (2013)