Darren J. Moore, PhD
Associate Professor, Center for Neurodegenerative Science and Head, Laboratory of Molecular Neurodegeneration at Van Andel Research Institute
Location: Grand Rapids, Michigan, United States
Darren J. Moore, PhD, leads the Laboratory of Molecular Neurodegeneration at the Van Andel Research Institute. Dr. Mooreís research focuses on investigating gene products associated with inherited forms of Parkinsonís disease, in particular, the LRRK2 and VPS35 genes.
Dr. Moore received his PhD in molecular neuroscience from the University of Cambridge in 2001 in the laboratory of Piers Emson, and conducted postdoctoral research with Ted Dawson in the Department of Neurology and Morris K. Udall Parkinsonís Disease Research Center of Excellence at the Johns Hopkins University School of Medicine. He joined the faculty of the Department of Neurology at Johns Hopkins in 2005 as an instructor and was appointed assistant professor in 2006. Prior to joining the Van Andel Research Institute in 2014, Dr. Moore was an assistant professor of life sciences at the Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Switzerland.
- Exploring the Mechanisms of Neuropathology in D620N VPS35 Knockin Mice (2018)
- Role of GTPase Activity in Neurodegenerative Phenotypes Induced by G2019S LRRK2 in a Pre-clinical Model of Parkinsonís Disease (2016)
- VPS35 as a Novel Target for Parkinson's Disease (2012)
- In Vivo Characterization of Helper-dependent Adenoviral Vectors Expressing Human LRRK2 (2012)
- Regulation of LRRK2 Activity by Nitric Oxide-Mediated Protein S-Nitrosylation (2011)
- Evaluation of ATP13A2 as a Molecular Target for Ameliorating Alpha-Synuclein-Induced Neurodegeneration in Pre-clinical Models of PD (2011)
- Validation of enzymatic activity and neuropathology in G2019S LRRK2-induced dopaminergic neurodegeneration in a pre-clinical model of Parkinson's disease (2010)
- Identification of LRRK2 Substrates in Pre-clinical Models of Parkinson's Disease (2009)
- Generation of Transgenic Mice with Selective and Progressive Loss of Nigrostriatal Dopaminergic Neurons (2006)