Jean-Christophe Rochet, PhD
Professor at Purdue University
Location: West Lafayette, Indiana, United States
Jean-Christophe (Chris) Rochet obtained his PhD degree in the Department of Biochemistry at the University of Alberta (Edmonton, Canada) in 1998. From 1999-2002, Dr. Rochet worked as a post-doctoral fellow with Dr. Peter Lansbury in the Department of Neurology at Harvard Medical School. His postdoctoral research (supported by a fellowship from the Human Frontier Science Program Organization) focused on the role of alpha-synuclein self-assembly in Parkinson's disease.
In the fall of 2002, Dr. Rochet joined the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University, where he is now a professor. The overall goals of his research program are to understand mechanisms of neurotoxicity and neuroprotection in PD by characterizing PD-related gene products (e.g., alpha-synuclein, DJ-1), and to use this information to develop new therapeutic strategies.
Dr. Rochet's honors include a Melvin Yahr Fellowship from the International Federation of Parkinson's Disease and a PhRMA Foundation Sabbatical Fellowship in Pharmacology and Toxicology.
- Neuroprotective Effects of NFE2L1 in Parkinson's Models (2018)
- Neuroprotective Effects of Endosulfine-alpha in Parkinson's Disease (2017)
- Neuroprotective Effects of Endosulfine-alpha in PD (2016)
- Determination of the 3D Structure of Biologically Active Small Molecules in Complex with DJ-1 (2013)
- Identification of Small-molecule Stabilizers of DJ-1: Biophysical and Cellular Validation (2010)
- Upregulation of MsrA: a neuroprotective strategy for the treatment of Parkinson's disease (2009)
- Impact of Post-Translational Modifications on the Neurotoxicity of Alpha-Synuclein in Parkinson's Disease (2007)