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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Repositioning Drugs for PD, 2012
    Amitriptyline as a Dopamine Neuroprotective Therapy

    Objective/Rationale:
    The project proposes to repurpose the tricyclic antidepressant medication, amitriptyline (AMI), as a disease-modifying therapy for Parkinson’s disease (PD). AMI is an FDA-approved...

  • Rapid Response Innovation Awards, 2008
    Effects of noradrenergic or serotoninergic system lesions combined with NS lesions on rodent models of 'non-motor'-like symptoms

    Objective/Rationale:
    Parkinson’s disease is widely attributed to neuropathy of dopaminergic neurones in the nigrostriatal (NS) pathway. Degeneration of noradrenergic and serotonergic neurones in the...

  • Clinical Intervention Awards, 2009
    MASTER PD: Magnetic Stimulation for the Treatment of Motor and Mood Symptoms of Parkinson's Disease: A Four-Center, Sham-Controlled, Parallel Group Study

    Objective/Rationale:
    To determine the efficacy and duration of benefit of noninvasive brain stimulation with repetitive transcranial magnetic stimulation (rTMS) to modulate brain activity in order to...

  • Diversity, Equity and Inclusivity in Parkinson's research, 2022
    Engaging the LGBTQIA+ Community, Caregivers and Care Providers in Research on Living with Parkinson’s Disease

    Study Rationale: Four million LGBTQIA+ adults age 50 and above live in the United States. We know very little about the needs of those in the LGBTQIA+ community who are living with Parkinson’s disease...

  • PD Subtypes, 2007
    Defining PD Subtypes Based on Patterns of Long-term Outcome

    The purpose of our study is to identify Parkinson’s disease subtypes based on how individuals are doing approximately seven to eight years after diagnosis. Some patients have few symptoms at this time...

  • Biomarkers, 2010
    Prospective Validation of Risk Markers for the Development of Parkinson’s Disease

    Promising Outcomes of Original Grant:
    As Parkinson’s disease is diagnosed when already a number of neurons have degenerated the PRIPS cohort consisting of 1847 healthy subjects older than 50 years was...

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