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Funding Opportunities

Therapeutic Pipeline Program


The Michael J. Fox Foundation seeks applications with potential for fundamentally altering disease course and/or significantly improving treatment of symptoms above and beyond current standards of care. The Therapeutic Pipeline Program is an Edmond J. Safra Core Program for PD Research.

Proposals must have a well-defined plan for moving toward clinical utility for Parkinson's disease (PD) patients. The Therapeutic Pipeline Program is open to industry and academic investigators proposing novel approaches or repositioning approved or clinically safe therapies from non-PD indications. The Therapeutic Pipeline Program advances Parkinson's disease therapeutic and intervention development along the pre-clinical and clinical path (i.e., both drug and non-pharmacological therapeutics, including gene therapy, biological, surgical and non-invasive approaches).

NEW: Applied Technologies as Treatments for Parkinson’s

Please note funding decisions for this category will be announced in November 2019.

The use of innovative technologies (e.g., assistive devices, wearable technologies) is an emerging and rapidly developing area offering new treatment opportunities for those with PD. Proposals should focus on testing the efficacy of novel devices and technologies designed to address critical, poorly managed symptoms of Parkinson’s disease. We are particularly interested in:

  • Proof-of-concept efficacy and/or feasibility studies from prototype or available devices and technologies
  • Analysis of existing clinical data sets from studies of applied technologies for evidence of clinical impact in people with PD

Note: Proposals to test remote monitoring devices that do not have a treatment focus (e.g., wearable activity trackers) or general exercise and rehabilitation approaches are not appropriate for this program

Disease-modifying Strategies

The goal of all proposals should be to protect or restore degenerating and/or dysfunctional neurons affected in PD. Proposals may target any of the following, though you are not restricted to this list:

  • Alpha-synuclein
  • GBA
  • Inflammation
  • LRRK2
  • Mitochondrial function
  • Protein folding

Symptomatic Strategies

The goal of these proposals should be to significantly improve treatment of symptoms above and beyond current standards of care. Proposals may aim to achieve any of the following:

  • Alleviate motor symptoms of PD
  • Alleviate non-motor symptoms of PD
  • Reduce complications and side effects of current PD treatments

Informational Webinar

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Application Process

  1. Download RFA and application template.
  2. Log in or create account in the grant application portal.
  3. Submit your completed application.

Contact with questions

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