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  • Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders
    2024
    OPEN
    Title: Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders
    Author(s): José Miguel Flores-Fernández, Verena Pesch, Aishwarya Sriraman, Enrique Chimal-Juárez, Sara Amidian, Xiongyao Wang, Caleb Duckering, Andrew Fang, Sara Reithofer, Liang Ma, Leonardo M. Cortez, Valerie L. Sim, Gültekin Tamgüney, Holger Wille
    Journal Name: Bioengineering & Translational Medicine
    Publisher: Wiley
    Vol: 9
    Issue #: 4
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1002/btm2.10665
    Best OA location URL:
    Citation Count: 0
  • [125I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [18F]Flotaza and [125I]IBETA in Postmortem Human Alzheimer’s Disease
    2024
    OPEN
    Title: [125I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [18F]Flotaza and [125I]IBETA in Postmortem Human Alzheimer’s Disease
    Author(s): Christopher Liang, Cayz G. Paclibar, Noresa L. Gonzaga, Stephanie A. Sison, Harman S. Bath, Agnes P. Biju, Jogeshwar Mukherjee
    Journal Name: Neurology International
    Publisher: MDPI AG
    Vol: 16
    Issue #: 2
    Start Page: 419
    End Page: 431
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.3390/neurolint16020031
    Best OA location URL:
    Citation Count: 3
  • Factors Influencing Patient Disclosure of Parkinson's Disease Genetic Testing Results to Relatives
    2024
    OPEN
    Title: Factors Influencing Patient Disclosure of Parkinson's Disease Genetic Testing Results to Relatives
    Author(s): Jeanine Schulze, Jasmine Kaur Dhaliwal, Mandy Miller, Emily A. Quinn, Leah Wetherill, Lola Cook
    Journal Name: Movement Disorders Clinical Practice
    Publisher: Wiley
    Vol: 11
    Issue #: 7
    Start Page: 786
    End Page: 794
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1002/mdc3.14043
    Best OA location URL:
    Citation Count: 0
  • A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy
    2024
    OPEN
    Title: A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy
    Author(s): Dan Tudorica, Bishal Basak, Alexia S. Puerta Cordova, Grace Khuu, Kevin Rose, Michael Lazarou, Erika L.F. Holzbaur, James H. Hurley
    Journal Name: Journal of Cell Biology
    Publisher: Rockefeller University Press
    Vol: 223
    Issue #: 7
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.1083/jcb.202309015
    Best OA location URL: https://rupress.org/jcb/article-pdf/223/7/e202309015/1928200/jcb_202309015.pdf
    Citation Count: 4
  • An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
    2024
    OPEN
    Title: An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
    Author(s): Marie‐France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.‐Q. Chen, Michaël Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor Goldsmith, Alexandria Schneider, Sonia Dorion, Nathalia Aprahamian, Adam MacDonald, Rhalena A. Thomas, Roy Dudley, Jeffrey A. Hall, Edward A. Fon, Jack P. Antel, Jo Anne Stratton, Thomas M. Durcan, Roberta La Piana, Luke M. Healy
    Journal Name: Molecular Neurodegeneration
    Publisher: Springer Science and Business Media LLC
    Vol: 19
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1186/s13024-024-00723-x
    Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/s13024-024-00723-x
    Citation Count: 0
  • Fusion of biomedical imaging studies for increased sample size and diversity: a case study of brain MRI
    2024
    OPEN
    Title: Fusion of biomedical imaging studies for increased sample size and diversity: a case study of brain MRI
    Author(s): Matias Aiskovich, Eduardo Castro, Jenna Reinen, Shreyas Fadnavis, Anushree Mehta, Hongyang Li, Amit Dhurandhar, Guillermo Cecchi, Pablo Polosecki
    Journal Name: Frontiers in Radiology
    Publisher: Frontiers Media SA
    Vol: 4
    Issue #:
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.3389/fradi.2024.1283392
    Best OA location URL:
    Citation Count: 0
  • Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
    2024
    OPEN
    Title: Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
    Author(s): Jean-Louis Parmasad, Konrad M. Ricke, Benjamin Nguyen, Morgan G. Stykel, Brodie Buchner-Duby, Amanda S. Bruce, Haley Geertsma, Eric Lian, Nathalie A. Lengacher, Steve Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Jiyan Ma, Patrik Brundin, Scott D. Ryan, Maxime W.C. Rousseaux
    Journal Name: Cell Death & Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 15
    Issue #: 4
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.1038/s41419-024-06534-8
    Best OA location URL:
    Citation Count: 1
  • Orthogonal analysis of mitochondrial function in Parkinson’s disease patients
    2024
    OPEN
    Title: Orthogonal analysis of mitochondrial function in Parkinson’s disease patients
    Author(s): Sander Barnhoorn, Chiara Milanese, Tracy Li, Lone Dons, Mehrnaz Ghazvini, M. Sette, Stefania Farina, Daisy Sproviero, César Payán‐Gómez, Pier G. Mastroberardino
    Journal Name: Cell Death & Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 15
    Issue #: 4
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41419-024-06617-6
    Best OA location URL: https://www.nature.com/articles/s41419-024-06617-6.pdf
    Citation Count: 0
  • RedOx regulation of LRRK2 kinase activity by active site cysteines
    2024
    OPEN
    Title: RedOx regulation of LRRK2 kinase activity by active site cysteines
    Author(s): Chiara R. Trilling, Jui-Hung Weng, Pallavi Kaila Sharma, Viktoria Nolte, Jian Wu, Wen Ma, Daniela Boassa, Susan S. Taylor, Friedrich W. Herberg
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 10
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-024-00683-5
    Best OA location URL:
    Citation Count: 2
  • Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease
    2024
    OPEN
    Title: Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease
    Author(s): Paulina González-Latapí, Bernabé I. Bustos, Siyuan Dong, Steven Lubbe, Tanya Simuni, Dimitri Krainc
    Journal Name: Annals of Neurology
    Publisher: Wiley
    Vol: 95
    Issue #: 6
    Start Page: 1162
    End Page: 1172
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1002/ana.26923
    Best OA location URL:
    Citation Count: 1
  • An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer’s Disease
    2024
    OPEN
    Title: An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer’s Disease
    Author(s): Xueyi Zhang, Lissette Gomez, Jennifer E. Below, Adam C. Naj, Eden R. Martin, Brian W. Kunkle, William S. Bush
    Journal Name: Journal of Alzheimer's Disease
    Publisher: IOS Press
    Vol: 98
    Issue #: 3
    Start Page: 1053
    End Page: 1067
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.3233/jad-231075
    Best OA location URL:
    Citation Count: 2
  • DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease
    2024
    OPEN
    Title: DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease
    Author(s): Seong‐Jin Yu, Yun Wang, Hui Shen, Eun-Kyung Bae, Yazhou Li, Kumar Sambamurti, Michael A. Tones, Margaret M. Zaleska, Barry J. Hoffer, Nigel H. Greig
    Journal Name: GeroScience
    Publisher: Springer Science and Business Media LLC
    Vol: 46
    Issue #: 5
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1007/s11357-024-01116-0
    Best OA location URL:
    Citation Count: 1
  • Identification and structural characterization of small molecule inhibitors of PINK1
    2024
    OPEN
    Title: Identification and structural characterization of small molecule inhibitors of PINK1
    Author(s): Shafqat Rasool, Tara Shomali, Luc Truong, Nathalie Croteau, Simon Veyron, Bernardo A. Bustillos, Wolfdieter Springer, Fabienne C. Fiesel, Jean‐François Trempe
    Journal Name: Scientific Reports
    Publisher: Springer Science and Business Media LLC
    Vol: 14
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41598-024-58285-3
    Best OA location URL:
    Citation Count: 0
  • Real-World Experiences of Parkinson's Disease OFF Time and Role of Demographics
    2024
    OPEN
    Title: Real-World Experiences of Parkinson's Disease OFF Time and Role of Demographics
    Author(s): Radhika Devraj, Ahmad El Kouzi, Marlon R. Tracey
    Journal Name: Journal of Patient-Centered Research and Reviews
    Publisher: Aurora Health Care, Inc.
    Vol: 11
    Issue #: 1
    Start Page: 8
    End Page: 17
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.17294/2330-0698.2057
    Best OA location URL:
    Citation Count: 0
  • Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology
    2024
    OPEN
    Title: Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology
    Author(s): Lara Blömeke, Fabian Rehn, Victoria Kraemer‐Schulien, Janine Kutzsche, Marlene Pils, Tuyen Bujnicki, Piotr Lewczuk, Johannes Kornhuber, Silka Dawn Freiesleben, Luisa‐Sophie Schneider, Lukas Preis, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Andrea Lohse, Anja Schneider, Klaus Fließbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Katharina Büerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris‐Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Göerß, Christoph Laske, Matthias H. Munk, Carolin Sanzenbacher, Annika Spottke, Nina Roy‐Kluth, Michael T. Heneka, Frederic Brosseron, Michael Wagner, Steffen Wolfsgruber, Luca Kleineidam, Melina Stark, Matthias Schmid, Frank Jessen, Oliver Bannach, Dieter Willbold, Oliver Peters
    Journal Name: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
    Publisher: Wiley
    Vol: 16
    Issue #: 2
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1002/dad2.12589
    Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dad2.12589
    Citation Count: 0
  • Experimental capture of miRNA targetomes: disease-specific 3′UTR library-based miRNA targetomics for Parkinson’s disease
    2024
    OPEN
    Title: Experimental capture of miRNA targetomes: disease-specific 3′UTR library-based miRNA targetomics for Parkinson’s disease
    Author(s): Martin Hart, Fabian Kern, Claudia Fecher‐Trost, Lena Krammes, Ernesto Aparicio‐Puerta, Annika Engel, Pascal Hirsch, Viktoria Wagner, Verena Keller, Georges Pierre Schmartz, Stefanie Rheinheimer, Caroline Diener, Ulrike Fischer, Jens Mayer, Markus R. Meyer, Veit Flockerzi, Andreas Keller, Eckart Meese
    Journal Name: Experimental & Molecular Medicine
    Publisher: Springer Science and Business Media LLC
    Vol: 56
    Issue #: 4
    Start Page: 935
    End Page: 945
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s12276-024-01202-5
    Best OA location URL:
    Citation Count: 0
  • Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domains
    2024
    OPEN
    Title: Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domains
    Author(s): Gregory A. Cary, Jesse C. Wiley, Jake Gockley, S. Keegan, Sai Sruthi Amirtha Ganesh, Laura Heath, Robert R. Butler, Lara M. Mangravite, Benjamin A. Logsdon, Frank M. Longo, Allan I. Levey, Anna K Greenwood, Gregory W. Carter
    Journal Name: Alzheimer's & Dementia: Translational Research & Clinical Interventions
    Publisher: Wiley
    Vol: 10
    Issue #: 2
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1002/trc2.12461
    Best OA location URL:
    Citation Count: 3
  • Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease
    2024
    OPEN
    Title: Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease
    Author(s): Gennaro Pagano, Kirsten I. Taylor, Judith Cabrera, Tanya Simuni, Kenneth Marek, Ronald B. Postuma, Nicola Pavese, Fabrizio Stocchi, Kathrin Brockmann, Hanno Svoboda, Dylan Trundell, Annabelle Monnet, Rachelle S. Doody, Paulo Fontoura, Geoffrey A. Kerchner, Patrik Brundin, Tania Nikolcheva, Azad Bonni
    Journal Name: Nature Medicine
    Publisher: Springer Science and Business Media LLC
    Vol: 30
    Issue #: 4
    Start Page: 1096
    End Page: 1103
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41591-024-02886-y
    Best OA location URL:
    Citation Count: 10
  • RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction
    2024
    OPEN
    Title: RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction
    Author(s): Cécilia Tremblay, Sidra Aslam, Jessica E. Walker, Ileana Lorenzini, Anthony J. Intorcia, Richard Arce, Parichita Choudhury, Charles H. Adler, Holly A. Shill, Erika Driver‐Dunckley, Shyamal Mehta, Ignazio S. Piras, Christine M. Belden, Alireza Atri, Thomas G. Beach, Geidy E. Serrano
    Journal Name: Neurobiology of Disease
    Publisher: Elsevier BV
    Vol: 196
    Issue #:
    Start Page: 106514
    End Page: 106514
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1016/j.nbd.2024.106514
    Best OA location URL: https://doi.org/10.1016/j.nbd.2024.106514
    Citation Count: 1
  • The integrated stress response pathway and neuromodulator signaling in the brain: lessons learned from dystonia
    2024
    OPEN
    Title: The integrated stress response pathway and neuromodulator signaling in the brain: lessons learned from dystonia
    Author(s): Nicole Calakos, Zachary F. Caffall
    Journal Name: Journal of Clinical Investigation
    Publisher: American Society for Clinical Investigation
    Vol: 134
    Issue #: 7
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.1172/jci177833
    Best OA location URL:
    Citation Count: 1
  • Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease
    2024
    OPEN
    Title: Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease
    Author(s): Sofie Lövdal, Giulia Carli, Beatrice Orso, Michael Biehl, Dario Arnaldi, Pietro Mattioli, Annette Janzen, Elisabeth Sittig, Silvia Morbelli, Jan Booij, Wolfgang H. Oertel, Klaus L. Leenders, Sanne K. Meles
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 10
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-024-00685-3
    Best OA location URL: https://www.nature.com/articles/s41531-024-00685-3.pdf
    Citation Count: 1
  • Genotype–phenotype correlation in PRKN-associated Parkinson’s disease
    2024
    OPEN
    Title: Genotype–phenotype correlation in PRKN-associated Parkinson’s disease
    Author(s): Poornima Jayadev Menon, Louise‐Laure Mariani, Baptiste Criniere-Boizet, Thomas Courtin, Christelle Tesson, Fanny Casse, Melanie Ferrien, Louise‐Laure Mariani, Stéphanie Carvalho, François‐Xavier Lejeune, Sana Rebbah, Gaspard Martet, Marion Houot, Aymeric Lanore, Graziella Mangone, Emmanuel Roze, Marie Vidailhet, Jan Aasly, Ziv Gan‐Or, Eric Yu, Yves Dauvilliers, Alexander Zimprich, Volker Tomantschger, Walter Pirker, Ignacio Álvarez, Pau Pástor, Alessio Di Fonzo, Kailash P. Bhatia, Francesca Magrinelli, Henry Houlden, Raquel Real, Andrea Quattrone, Patricia Limousin, Prasad Korlipara, Thomas Foltynie, Donald G. Grosset, Nigel Williams, Derek P. Narendra, Hsin-Pin Lin, Čarna Jovanović, Marina Svetel, Timothy Lynch, Amy Gallagher, Wim Vandenberghe, Thomas Gasser, Kathrin Brockmann, Huw R. Morris, Max Borsche, Christine Klein, Olga Corti, Alexis Brice, Suzanne Lesage, Jean‐Christophe Corvol
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 10
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41531-024-00677-3
    Best OA location URL:
    Citation Count: 7
  • Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue
    2024
    OPEN
    Title: Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue
    Author(s): Dhruva Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Dominik Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Yu, Michaël Rau, Zachary Smith, Soumyo Sen, Brock Summers, John W. Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
    Journal Name: Nature Communications
    Publisher: Springer Science and Business Media LLC
    Vol: 15
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41467-024-46832-5
    Best OA location URL:
    Citation Count: 12
  • Development and characterization of a non-human primate model of disseminated synucleinopathy
    2024
    OPEN
    Title: Development and characterization of a non-human primate model of disseminated synucleinopathy
    Author(s): Alberto J. Rico, Almudena Corcho, Julia Chocarro, Goiaz Ariznabarreta, Elvira Roda, Adriana Honrubia, Patricia Arnáiz Castro, José L. Lanciego
    Journal Name: Frontiers in Neuroanatomy
    Publisher: Frontiers Media SA
    Vol: 18
    Issue #:
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.3389/fnana.2024.1355940
    Best OA location URL:
    Citation Count: 0
  • Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease
    2024
    RESTRICTED
    Title: Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease
    Author(s):
    Journal Name:
    Publisher: Cold Spring Harbor Laboratory
    Vol:
    Issue #:
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1101/2024.03.22.586364
    Best OA location URL:
    Citation Count:
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