To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
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SNCA Multiplication iPSC Lines*
Human iPS Cell
Isogenic iPSC lines harboring a triplication , duplication, single copy, or KO of the SNCA gene derived from a patient with the triplication mutation. These lines were generated and kindly deposited by Birgitt Schuele at Stanford University into the MJFF Sponsored Tools Program.
Parkin/PINK1 Double KO Rat
Rat Model
Knockout of Parkin and PINK1 in the Long Evans Hooded rat strain.
Oligomeric Alpha-Synuclein Protein*
Protein
Stable oligomeric aggregates of alpha-synuclein protein. Intended for use in biochemical assays (not intended for use in the pre-formed fibril model).
LRRK2 pT1410 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine1410 of LRRK2. Antibody is suitable for immunoblotting applications.
SNCA-GFP Knockin Mouse*
Mouse Model
Mouse expressing SNCA with GFP fused to the C-terminus resulting in expression of GFP-tagged alpha-synuclein under the control of endogenous regulatory elements. Model was generated and deposited by Kelvin Luk at University of Pennsylvania through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:035412
AAV2-CBA-eGFP
Viral Vector
Viral vector (AAV2 serotype) encoding eGFP to serve as a control vector. Produced by the UNC Vector Core.
Characterization data for this viral vector can be found here.
GBA E326K Knockin Mouse*
Mouse Model
Mouse expressing GBA E326K mutation and 3 silent mutations in exon 8 of the mouse Gba gene. Model was generated and deposited by Mark Cookson at NIH through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036159
Alpha-Synuclein A53T Knockin Mouse*
Mouse Model
Double transgenic homozygous mice which have PAC overexpression of human A53T alpha synuclein mutant form on an SNCA knockout mouse background. Model was generated and deposited by Robert Nussbaum at University of California San Francisco through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:010799
Parkin Knockout Mouse*
Mouse Model
Homozygous knockout mice with exon 3 mutation resulting in a frame shift and a premature stop codon in exon 5. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:006582
Human Alpha-Synuclein A53T Mouse*
Mouse Model
Transgenic mice expressing the A53T missense mutant form of human alpha-synuclein under the control of the murine prion promoter. Model was generated and deposited by Michael Lee at University of Minnesota through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:006823
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic