To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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LRRK2 iPSC Cell Line Collection*
Human iPS Cell
Human iPSC lines focused on pathogenic LRRK2 gene variants made available in collaboration with Dr. Birgitt Schuele at Stanford University School of Medicine. The series includes homozygous and heterozygous LRRK2 p.G2019S mutants, isogenic derivatives generated by Zinc Finger Nuclease (ZFN) editing (biallelic correction, knockout, and unedited controls), healthy controls, and a unique double-mutant line combining LRRK2 p.G2019S with a PARKIN (PRKN) exon 5 copy-number variation.
AAV1/2-CAG-A53T Alpha-Synuclein
Viral Vector
Viral Vector (AAV1/2 serotype) encoding alpha-synuclein with the A53T mutation. AAV1/2 empty vector available as a control in Reporter section and the AAV-CAG-A53T alpha-synuclein plasmid is available in the Plasmid section. This virus has been discontinued due to manufacturing challenges. Please use the AAV2/5 WT aSyn viral vector.
AAV1/2-CAG-empty vector
Viral Vector
Viral Vector (AAV1/2 serotype) to serve as a control vector for the AAV1/2-CAG-A53T aSyn viral vector. The AAV-CAG-empty vector plasmid is also available in the Plasmid section.This virus has been discontinued due to manufacturing challenges.
PPMI iPSCs
Human iPS Cell
Induced pluripotent stem cell (iPSC) lines are available through the PPMI repository. The repository includes lines from control, idiopathic PD, genetic PD (LRRK2, GBA, SNCA), genetic unaffected carriers (LRRK2, LRRK2/GBA, GBA, SNCA), and prodromal patients. Gene-revertant controls are available for select lines. An inventory of available lines can be found here: https://zenodo.org/records/10783308
TMEM192 Antibody (Ms)
Antibody
Rabbit monoclonal antibody directed against mouse TMEM192 for immunoprecipitation of lysosomes. A version of this antibody conjugated to magnetic beads is also available. This antibody was generated by Dr. Dario Alessi at the University of Dundee and deposited through the MJFF Sponsored Tools Program as part of the Aligning Science Across Parkinson’s (ASAP) Initiative.
Bead-Conjugated TMEM192 Antibody (Ms)
Antibody
Magnetic bead-conjugated rabbit monoclonal antibody directed against mouse TMEM192 for immunoprecipitation of lysosomes. An unconjugated version of this antibody is also available. This antibody was generated by Dr. Dario Alessi at the University of Dundee and deposited through the MJFF Sponsored Tools Program as part of the Aligning Science Across Parkinson’s (ASAP) Initiative.
Bead-Conjugated TMEM192 Antibody (Hu)
Antibody
Magnetic bead-conjugated rabbit monoclonal antibody directed against human TMEM192 for immunoprecipitation of lysosomes. An unconjugated version of this antibody is also available. This antibody was generated by Dr. Dario Alessi at the University of Dundee and deposited through the MJFF Sponsored Tools Program as part of the Aligning Science Across Parkinson’s (ASAP) Initiative. For 500uL and 1mL aliquot sizes, use MJFF discount code MJFFAB. Custom orders are recommended if volume needs exceed 1mL.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic