3051 - 3100 of 6284 Results
Title
Year
-
OPENTitle: The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer’s Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of AgingJournal Name: Journal of Alzheimer's DiseasePublisher: SAGE PublicationsVol: 60Issue #: 3Start Page: 819End Page: 828Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jad-160925Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5493514Citation Count: 68
-
OPENTitle: Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regenerationJournal Name: Acta BiomaterialiaPublisher: Elsevier BVVol: 38Issue #:Start Page: 44End Page: 58Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.actbio.2016.04.021Citation Count: 81
-
OPENTitle: Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trialsJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 127Issue #: 6Start Page: 861End Page: 879Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-014-1256-4Citation Count: 216
-
OPENTitle: CSF xanthine, homovanillic acid, and their ratio as biomarkers of Parkinson's diseaseJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1408Issue #:Start Page: 88End Page: 97Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.brainres.2011.06.057Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4120020Citation Count: 74
-
OPENTitle: Your algorithm might think the hippocampus grows in Alzheimer's disease: Caveats of longitudinal automated hippocampal volumetryJournal Name: Human Brain MappingPublisher: WileyVol: 38Issue #: 6Start Page: 2875End Page: 2896Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/hbm.23559Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.23559Citation Count: 25
-
OPENTitle: Temporal Expression of Mutant LRRK2 in Adult Rats Impairs Dopamine ReuptakeJournal Name: International Journal of Biological SciencesPublisher: Ivyspring International PublisherVol: 7Issue #: 6Start Page: 753End Page: 761Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.7150/ijbs.7.753Best OA location URL: https://www.ijbs.com/v07p0753.pdfCitation Count: 58
-
OPENTitle: Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicityJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol: 22Issue #: 2Start Page: 328End Page: 344Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/hmg/dds431Best OA location URL: https://academic.oup.com/hmg/article-pdf/22/2/328/1857445/dds431.pdfCitation Count: 76
-
OPENTitle: Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypesJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol: 23Issue #: 17Start Page: 4693End Page: 4702Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/hmg/ddu158Best OA location URL: https://academic.oup.com/hmg/article-pdf/23/17/4693/2193406/ddu158.pdfCitation Count: 61
-
OPENTitle: Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 DomainJournal Name: Molecular and Cellular BiologyPublisher: Informa UK LimitedVol: 34Issue #: 12Start Page: 2147End Page: 2161Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1128/mcb.00914-13Best OA location URL: http://doi.org/10.1128/MCB.00914-13Citation Count: 99
-
OPENTitle: Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling PathwayJournal Name: Molecular and Cellular BiologyPublisher: Informa UK LimitedVol: 35Issue #: 11Start Page: 1992End Page: 2006Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1128/mcb.01510-14Best OA location URL: https://mcb.asm.org/content/mcb/35/11/1992.full.pdfCitation Count: 21
-
OPENTitle: Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent miceJournal Name: Molecular and Cellular NeurosciencePublisher: Elsevier BVVol: 47Issue #: 4Start Page: 286End Page: 292Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.mcn.2011.05.006Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3149813Citation Count: 47
-
OPENTitle: Parkinson's disease, cortical dysfunction, and alpha‐synucleinJournal Name: Movement DisordersPublisher: WileyVol: 26Issue #: 8Start Page: 1436End Page: 1442Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.23697Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3154995Citation Count: 23
-
OPENTitle: The Unified Parkinson�s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory functionJournal Name: The Journal of Rehabilitation Research and DevelopmentPublisher: Journal of Rehabilitation Research & DevelopmentVol: 49Issue #: 8Start Page: 1269End Page: 1269Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1682/jrrd.2011.06.0103Citation Count: 27
-
OPENTitle: Impaired perception of biological motion in Parkinson’s disease.Journal Name: NeuropsychologyPublisher: American Psychological Association (APA)Vol: 30Issue #: 6Start Page: 720End Page: 730Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1037/neu0000276Best OA location URL: https://doi.org/10.1037/neu0000276Citation Count: 49
-
OPENTitle: Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 56Issue #: 6-7Start Page: 944End Page: 955Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2009.01.020Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3820009Citation Count: 46
-
OPENTitle: Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s diseaseJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-017-0007-3Best OA location URL: https://www.nature.com/articles/s41531-017-0007-3.pdfCitation Count: 32
-
OPENTitle: Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working MemoryJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 41Issue #: 9Start Page: 2224End Page: 2231Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/npp.2016.14Best OA location URL: https://www.nature.com/articles/npp201614.pdfCitation Count: 27
-
OPENTitle: Morphological Alterations in the Thalamus, Striatum, and Pallidum in Autism Spectrum DisorderJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 41Issue #: 11Start Page: 2627End Page: 2637Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/npp.2016.64Best OA location URL: https://www.nature.com/articles/npp201664.pdfCitation Count: 145
-
OPENTitle: mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shellJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 43Issue #: 10Start Page: 2075End Page: 2082Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0049-1Best OA location URL: https://www.nature.com/articles/s41386-018-0049-1.pdfCitation Count: 30
- Different PD-MCI criteria and risk of dementia in Parkinson’s disease: 4-year longitudinal study2016OPENTitle: Different PD-MCI criteria and risk of dementia in Parkinson’s disease: 4-year longitudinal studyJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 2Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/npjparkd.2015.27Best OA location URL: https://www.nature.com/articles/npjparkd201527.pdfCitation Count: 71
-
OPENTitle: Use of a self-rating scale of the nature and severity of symptoms in Parkinson’s Disease (PRO-PD): Correlation with quality of life and existing scales of disease severityJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-017-0021-5Best OA location URL: https://www.nature.com/articles/s41531-017-0021-5.pdfCitation Count: 41
- Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat2018OPENTitle: Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the ratJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-018-0066-0Best OA location URL: https://www.nature.com/articles/s41531-018-0066-0.pdfCitation Count: 56
-
OPENTitle: Presence of Striatal Amyloid Plaques in Parkinson's Disease Dementia Predicts Concomitant Alzheimer's Disease: Usefulness for Amyloid ImagingJournal Name: Journal of Parkinson’s DiseasePublisher: SAGE PublicationsVol: 2Issue #: 1Start Page: 57End Page: 65Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jpd-2012-11073Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3423968Citation Count: 40
-
OPENTitle: Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppressionJournal Name: Neural DevelopmentPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1749-8104-4-11Best OA location URL: https://neuraldevelopment.biomedcentral.com/counter/pdf/10.1186/1749-8104-4-11Citation Count: 40
-
OPENTitle: Conventional 3T brain MRI and diffusion tensor imaging in the diagnostic workup of early stage parkinsonismJournal Name: NeuroradiologyPublisher: Springer Science and Business Media LLCVol: 57Issue #: 7Start Page: 655End Page: 669Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00234-015-1515-7Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00234-015-1515-7.pdfCitation Count: 42
-
OPENTitle: Parkinson's disease cognitive network correlates with caudate dopamineJournal Name: NeuroImagePublisher: Elsevier BVVol: 78Issue #:Start Page: 204End Page: 209Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroimage.2013.03.070Best OA location URL: http://doi.org/10.1016/j.neuroimage.2013.03.070Citation Count: 91
-
OPENTitle: Hemispheric asymmetry of electroencephalography-based functional brain networksJournal Name: NeuroReportPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 25Issue #: 16Start Page: 1266End Page: 1271Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/wnr.0000000000000256Citation Count: 10
-
OPENTitle: Deep brain stimulation for levodopa-refractory benign tremulous parkinsonismJournal Name: Neurologia i Neurochirurgia PolskaPublisher: VM Media SP. zo.o VM Group SKVol: 50Issue #: 5Start Page: 383End Page: 386Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.pjnns.2016.05.008Best OA location URL: https://www.sciencedirect.com/science/article/pii/S0028384316300573Citation Count: 1
-
OPENTitle: Is PARKIN parkinsonism a cancer predisposition syndrome?Journal Name: Neurology GeneticsPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 1Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1212/nxg.0000000000000031Best OA location URL: https://ng.neurology.org/content/nng/1/4/e31.full.pdfCitation Count: 4
-
OPENTitle: LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexJournal Name: Frontiers in Molecular NeurosciencePublisher: Frontiers Media SAVol: 7Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnmol.2014.00049Best OA location URL: https://www.frontiersin.org/articles/10.3389/fnmol.2014.00049/pdfCitation Count: 97
-
OPENTitle: Nicotinic receptor agonists decrease L-dopa-induced dyskinesias most effectively in partially lesioned parkinsonian ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 60Issue #: 6Start Page: 861End Page: 868Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2010.12.032Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3133531Citation Count: 71
-
OPENTitle: Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 60Issue #: 2-3Start Page: 284End Page: 294Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2010.09.011Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3820002Citation Count: 20
-
OPENTitle: Characterization of RNA isolated from eighteen different human tissues: results from a rapid human autopsy programJournal Name: Cell and Tissue BankingPublisher: Springer Science and Business Media LLCVol: 17Issue #: 3Start Page: 361End Page: 375Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s10561-016-9555-8Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5026224Citation Count: 69
-
OPENTitle: Domain‐specific cognitive impairment in non‐demented Parkinson's disease psychosisJournal Name: International Journal of Geriatric PsychiatryPublisher: WileyVol: 33Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/gps.4736Citation Count: 10
-
OPENTitle: Droxidopa and Reduced Falls in a Trial of Parkinson Disease Patients With Neurogenic Orthostatic HypotensionJournal Name: Clinical NeuropharmacologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 39Issue #: 5Start Page: 220End Page: 226Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1097/wnf.0000000000000168Best OA location URL: https://doi.org/10.1097/wnf.0000000000000168Citation Count: 56
-
OPENTitle: LRRK2 G2019S mutations may be increased in Puerto RicansJournal Name: Movement DisordersPublisher: WileyVol: 26Issue #: 9Start Page: 1771End Page: 1773Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.23632Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3140626Citation Count: 8
-
OPENTitle: Racial differences may influence the role of cholecystokinin polymorphisms in Parkinson's disease hallucinationsJournal Name: Movement DisordersPublisher: WileyVol: 26Issue #: 9Start Page: 1781End Page: 1783Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.23655Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3142314Citation Count: 19
-
OPENTitle: Zinc inhibition of rat NR1/NR2AN‐methyl‐d‐aspartate receptorsJournal Name: The Journal of PhysiologyPublisher: WileyVol: 586Issue #: 3Start Page: 763End Page: 778Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1113/jphysiol.2007.143941Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2375611Citation Count: 63
-
OPENTitle: Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microgliaJournal Name: Journal of NeuroinflammationPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12974-014-0164-9Best OA location URL: https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-014-0164-9Citation Count: 29
-
OPENTitle: Alpha-Synuclein Pathology and Axonal Degeneration of the Peripheral Motor Nerves Innervating Pharyngeal Muscles in Parkinson DiseaseJournal Name: Journal of Neuropathology & Experimental NeurologyPublisher: Oxford University Press (OUP)Vol: 72Issue #: 2Start Page: 119End Page: 129Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/nen.0b013e3182801cdeBest OA location URL: https://academic.oup.com/jnen/article-pdf/72/2/119/9562323/72-2-119.pdfCitation Count: 142
- Dentate nucleus iron deposition is a potential biomarker for tremor‐dominant Parkinson's disease2016OPENTitle: Dentate nucleus iron deposition is a potential biomarker for tremor‐dominant Parkinson's diseaseJournal Name: NMR in BiomedicinePublisher: WileyVol: 30Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/nbm.3554Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4906439Citation Count: 54
-
OPENTitle: Comparative study of the neurotrophic effects elicited by VEGF-B and GDNF in preclinical in vivo models of Parkinson’s diseaseJournal Name: NeurosciencePublisher: Elsevier BVVol: 258Issue #:Start Page: 385End Page: 400Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroscience.2013.11.038Citation Count: 51
-
OPENTitle: Do Stable Patients With a Premorbid Depression History Have a Worse Outcome After Deep Brain Stimulation for Parkinson Disease?Journal Name: NeurosurgeryPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 69Issue #: 2Start Page: 357End Page: 361Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1227/neu.0b013e3182160456Citation Count: 23
-
OPENTitle: Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domainJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 111Issue #: 11Start Page: 4055End Page: 4060Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1323285111Best OA location URL: https://www.pnas.org/content/pnas/111/11/4055.full.pdfCitation Count: 109
-
OPENTitle: Large-scale replication and heterogeneity in Parkinson disease genetic lociJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 79Issue #: 7Start Page: 659End Page: 667Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318264e353Best OA location URL: https://n.neurology.org/content/neurology/79/7/659.full.pdfCitation Count: 128
-
OPENTitle: GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synucleinJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 105Issue #: 31Start Page: 10907End Page: 10912Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0802437105Best OA location URL: https://www.pnas.org/content/pnas/105/31/10907.full.pdfCitation Count: 258
-
OPENTitle: Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomasJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 108Issue #: 4Start Page: 1439End Page: 1444Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1012500108Citation Count: 88
-
OPENTitle: Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegenerationJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 110Issue #: 1Start Page: 300End Page: 305Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1217296110Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3538212Citation Count: 115
-
OPENTitle: Parkinson‘s Disease: What Role Do Pedunculopontine Cholinergic Neurons Play?Journal Name: Future NeurologyPublisher: Informa UK LimitedVol: 9Issue #: 1Start Page: 5End Page: 8Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.2217/fnl.13.61Citation Count: 6
-
OPENTitle: Mechanism of parkin activation by PINK1Journal Name: NaturePublisher: Springer Science and Business Media LLCVol: 559Issue #: 7714Start Page: 410End Page: 414Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41586-018-0224-xBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6071873Citation Count: 326