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MJFF Publications

The Michael J. Fox Foundation continually strives to communicate our scientific progress with the research community — through posters and presentations at meetings, in peer-reviewed scientific publications and with white paper reports.

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    Overview of Parkin Models

    Mutations in the parkin gene cause autosomal recessive, young onset Parkinson’s disease (PD). The PD-linked mutations in parkin lead to loss of expression/function of the Parkin protein, an E3…
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    Overview of PINK1 Models

    Mutations in the PTEN-induced kinase 1 (PINK1)  gene cause autosomal recessive, young onset Parkinson’s disease (PD). The PD-linked mutations in PINK1 lead to loss of expression/function of the PINK1…
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    Overview of Mitochondrial Dysfunction Models

    Mitochondrial function is a pathway of great interest for Parkinson’s disease (PD) research and therapeutic development given the dysfunction that has been observed in idiopathic patients, patients…
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    Overview of Inflammation Models

    Inflammation is a pathway of great interest for Parkinson’s disease (PD) research and therapeutic development given evidence of innate and adaptive immune changes in PD patients. Inflammation is also…
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    Overview of NLRP3 Models

    NLRP3 has arisen as a target of interest for Parkinson’s disease (PD) given increased levels seen in patient brain and preclinical studies showing inhibition of NLRP3 decreases pathology and motor…
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    Overview of GBA1 Models

    The most common genetic form of Parkinson’s disease (PD) is caused by heterozygous mutations in the GBA1 gene which encodes the lysosomal enzyme GCase, leading to decreased activity and accumulation…
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    Overview of LRRK2 Models

    The mutations in the LRRK2 gene which increase the LRRK2 kinase activity are a common genetic form of Parkinson’s disease (PD). The most common mutation is the G2019S mutation which increases kinase…
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Articles authored by Rachel Dolhun, MD, a movement disorder specialist on staff at MJFF, offer a practical review of topics related to Parkinson's disease for practicing clinicians.

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    Alpha-Synuclein: A Therapeutic Target and Potential Biomarker in Parkinson's Disease

    A detailed discussion of our current understanding of alpha-synuclein biology and the ongoing research and development surrounding its role in Parkinson's disease.
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    Diagnosis and Management of Neurodegenerative Atypical Parkinsonism

    A detailed consideration of the neurodegenerative diseases that can cause parkinsonism including dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP)…
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    Deep Brain Stimulation and Magnetic Resonance-guided Focused Ultrasound

    A review of innovations in surgical Parkinson's disease treatments, inlcuding deep brain stimulation and magnetic resonance-guided focused ultrasound.
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    Dystonia and Parkinson's Disease

    An exploration of the various manifestations of dystonia in the context of Parkinson's disease.
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    Levodopa 2.0: New Strategies to Even Out the Peaks and Valleys

    A discussion on the latest in new formulations and supplemental therapies of levodopa.
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    Dementia with Lewy Bodies: In the News and in the Clinic

    A practical review of the diagnosis and management of dementia with Lewy bodies.
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Michael J. Fox Foundation publications supported through our OAP program.

We believe that the results of all MJFF-funded research should be promptly published and broadly disseminated to accelerate innovation and foster collaboration toward our shared goal of new treatments and cures for Parkinson’s disease. 

Request open access coverage funds for your MJFF project here

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    Evaluation of the PREDIGT Score’s Performance in Identifying Newly Diagnosed Parkinson’s Patients Without Motor Examination

    Several recent publications described algorithms to identify subjects with Parkinson’s disease (PD). In creating the “PREDIGT Score”, we previously developed a hypothesis-driven, simple-to-use…
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    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease

    Leucine-rich repeat kinase 2 (LRRK2) is a kinase involved in different cellular functions, including autophagy, endolysosomal pathways, and immune function. Mutations in LRRK2 cause autosomal…
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    Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms

    Background: The development of therapeutics for Parkinson's disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression, and assessing…
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    Cortical and Subthalamic Nucleus Spectral Changes During Limb Movements in Parkinson's Disease Patients with and Without Dystonia

    Background: Dystonia is an understudied motor feature of Parkinson's disease (PD). Although considerable efforts have focused on brain oscillations related to the cardinal symptoms of PD, whether…
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    Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy

    Synucleinopathy (Parkinson's disease (PD); Lewy body dementia) disease-modifying treatments represent a huge unmet medical need. Although the PD-causing protein α-synuclein (αS) interacts with lipids…
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    Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts

    Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase activity in clinical biofluids remain urgently needed. A variety of targets and approaches have been…
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    Longitudinal Cohort Study of Verbatim-Reported Postural Instability Symptoms as Outcomes for Online Parkinson's Disease Trials

    Background: The Parkinson's Disease Patient Report of Problems (PD-PROP) captures the problems and functional impact that patients report verbatim. Online research participation and advances in…
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Female researcher pipetting in lab.

Breaking Research Updates

Read the latest developments in the field’s understanding and treatment of Parkinson’s disease.

Read Research News
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