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MJFF Publications

The Michael J. Fox Foundation continually strives to communicate our scientific progress with the research community — through posters and presentations at meetings, in peer-reviewed scientific publications and with white paper reports.

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    Overview of Olfactory Dysfunction Models

    Olfactory dysfunction is a common issue in Parkinson’s disease (PD), affecting 70-95% of patients. Symptoms include impairments in odor detection, identification, and discrimination. Interestingly,…
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    Overview of Cognitive Dysfunction Models

    Cognitive dysfunction is a common issue in Parkinson’s disease (PD). Symptoms include impairments in working memory, learning, attention, cognitive flexibility, and social cognition. Cognitive…
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    MJFF LRRK2 Mouse Motor Phenotyping Study

    MJFF phenotyped the motor function of the various LRRK2 mouse models generated through the Research Tools Program.  Models include WT LRRK2 BAC, G2019S LRRK2 BAC, R1441G LRRK2 BAC, LRRK2 KO, LRRK1 KO…
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    MJFF Alpha-Synuclein KO and A53T KI Rat Characterization Study

    MJFF performed extensive phenotyping of the aSyn KO and humanized A53T aSyn KI rats that were generated through the MJFF Research Tools Program. Assessments were made at multiple timepoints and…
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    MJFF Alpha-Synuclein Mouse Comparison Study

    MJFF funded a study to compare multiple common alpha-synuclein mouse models to understand their PD-related phenotypes at 4, 8, and 12 months of age. Lines include Thy-1 aSyn Line 15 Tg (MJFF), Thy-1…
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    Analysis of Genetic Mutations in the BioFIND Cohort

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    Overview of GI Dysfunction Models

    Gastrointestinal (GI) dysfunction is a common issue in Parkinson’s disease (PD). Symptoms including dysphagia, bloating, and constipation, with constipation often reported decades before motor…
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Articles authored by Rachel Dolhun, MD, a movement disorder specialist on staff at MJFF, offer a practical review of topics related to Parkinson's disease for practicing clinicians.

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    Alpha-Synuclein: A Therapeutic Target and Potential Biomarker in Parkinson's Disease

    A detailed discussion of our current understanding of alpha-synuclein biology and the ongoing research and development surrounding its role in Parkinson's disease.
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    Diagnosis and Management of Neurodegenerative Atypical Parkinsonism

    A detailed consideration of the neurodegenerative diseases that can cause parkinsonism including dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP)…
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    Deep Brain Stimulation and Magnetic Resonance-guided Focused Ultrasound

    A review of innovations in surgical Parkinson's disease treatments, inlcuding deep brain stimulation and magnetic resonance-guided focused ultrasound.
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    Dystonia and Parkinson's Disease

    An exploration of the various manifestations of dystonia in the context of Parkinson's disease.
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    Levodopa 2.0: New Strategies to Even Out the Peaks and Valleys

    A discussion on the latest in new formulations and supplemental therapies of levodopa.
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    Dementia with Lewy Bodies: In the News and in the Clinic

    A practical review of the diagnosis and management of dementia with Lewy bodies.
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Michael J. Fox Foundation publications supported through our OAP program.

We believe that the results of all MJFF-funded research should be promptly published and broadly disseminated to accelerate innovation and foster collaboration toward our shared goal of new treatments and cures for Parkinson’s disease. 

Request open access coverage funds for your MJFF project here

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    Evaluation of the PREDIGT Score’s Performance in Identifying Newly Diagnosed Parkinson’s Patients Without Motor Examination

    Several recent publications described algorithms to identify subjects with Parkinson’s disease (PD). In creating the “PREDIGT Score”, we previously developed a hypothesis-driven, simple-to-use…
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    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease

    Leucine-rich repeat kinase 2 (LRRK2) is a kinase involved in different cellular functions, including autophagy, endolysosomal pathways, and immune function. Mutations in LRRK2 cause autosomal…
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    Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms

    Background: The development of therapeutics for Parkinson's disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression, and assessing…
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    Cortical and Subthalamic Nucleus Spectral Changes During Limb Movements in Parkinson's Disease Patients with and Without Dystonia

    Background: Dystonia is an understudied motor feature of Parkinson's disease (PD). Although considerable efforts have focused on brain oscillations related to the cardinal symptoms of PD, whether…
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    Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy

    Synucleinopathy (Parkinson's disease (PD); Lewy body dementia) disease-modifying treatments represent a huge unmet medical need. Although the PD-causing protein α-synuclein (αS) interacts with lipids…
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    Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts

    Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase activity in clinical biofluids remain urgently needed. A variety of targets and approaches have been…
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    Longitudinal Cohort Study of Verbatim-Reported Postural Instability Symptoms as Outcomes for Online Parkinson's Disease Trials

    Background: The Parkinson's Disease Patient Report of Problems (PD-PROP) captures the problems and functional impact that patients report verbatim. Online research participation and advances in…
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Breaking Research Updates

Read the latest developments in the field’s understanding and treatment of Parkinson’s disease.

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