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MJFF Publications

The Michael J. Fox Foundation continually strives to communicate our scientific progress with the research community — through posters and presentations at meetings, in peer-reviewed scientific publications and with white paper reports.

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    LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

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    The Michael J. Fox Foundation’s Efforts to Understand the Relationship between GBA1 and Alpha-Synuclein through the Development and Characterization of Preclinical Models

    Heterozygous mutations in the GBA1 gene--which encodes for lysosomal glucocerebrosidase (GCase)--are the most common genetic risk factor for Parkinson’s disease (PD). In addition, decreased GCase…
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    The Michael J. Fox Foundation’s Efforts to Develop New Tools for Understanding LRRK2 Biology and the Role of LRRK2 in Parkinson’s Disease Pathology

    As the greatest known genetic contributor to Parkinson's disease (PD), the leucine-rich repeat kinase 2 (LRRK2) gene and protein are targets of interest for Parkinson’s disease research and…
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    Characterization of a humanized A53T alpha-synuclein (aSyn A53T KI) and alpha-synuclein KO (aSyn KO) models

    Mutations and multiplications in the SNCA gene encoding the alpha-synuclein protein are linked to an autosomal dominant form of Parkinson’s disease (PD). One such mutation is the alanine-to-threonine…
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    The Michael J. Fox Foundation’s Strategy to Generate, Characterize, and Distribute Preclinical Antibody Tools for Investigating Rab Molecular Biology

    A field-wide challenge in Parkinson’s disease (PD) research is a general lack of availability for high-quality, reproducible, and readily accessible preclinical research tools. To address these…
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    Cell Line Resources from Parkinson’s Progression Markers Initiative (PPMI) Participants

    The Parkinson’s Progression Markers Initiative (PPMI) is a longitudinal observational study conducted at over thirty international sites that collects data and biospecimens from idiopathic Parkinson…
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    LRRK2 Detection in PBMC Consortium

    The “LRRK2 Detection in PBMC Consortium” is a pre-competitive collaboration between MJFF and select industry partners with the goal of optimizing the measurement of pLRRK2 in human PBMCs. MJFF…
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Articles authored by Rachel Dolhun, MD, a movement disorder specialist on staff at MJFF, offer a practical review of topics related to Parkinson's disease for practicing clinicians.

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    Alpha-Synuclein: A Therapeutic Target and Potential Biomarker in Parkinson's Disease

    A detailed discussion of our current understanding of alpha-synuclein biology and the ongoing research and development surrounding its role in Parkinson's disease.
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    Diagnosis and Management of Neurodegenerative Atypical Parkinsonism

    A detailed consideration of the neurodegenerative diseases that can cause parkinsonism including dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP)…
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    Deep Brain Stimulation and Magnetic Resonance-guided Focused Ultrasound

    A review of innovations in surgical Parkinson's disease treatments, inlcuding deep brain stimulation and magnetic resonance-guided focused ultrasound.
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    Dystonia and Parkinson's Disease

    An exploration of the various manifestations of dystonia in the context of Parkinson's disease.
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    Levodopa 2.0: New Strategies to Even Out the Peaks and Valleys

    A discussion on the latest in new formulations and supplemental therapies of levodopa.
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    Dementia with Lewy Bodies: In the News and in the Clinic

    A practical review of the diagnosis and management of dementia with Lewy bodies.
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Michael J. Fox Foundation publications supported through our OAP program.

We believe that the results of all MJFF-funded research should be promptly published and broadly disseminated to accelerate innovation and foster collaboration toward our shared goal of new treatments and cures for Parkinson’s disease. 

Request open access coverage funds for your MJFF project here

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    Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model

    Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid…
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    Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor

    Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer's disease (AD) and other tauopathies, but it is unclear how neuroanatomical connections,…
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    Fyn knockdown prevents levodopa-induced dyskinesia in a mouse model of Parkinson's disease

    Dopamine replacement by levodopa is the most widely used therapy for Parkinson's disease (PD), however patients often develop side effects, known as levodopa-induced dyskinesia (LID), that usually…
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    Video-based Parkinson’s disease assessments in a nationwide cohort of Fox Insight participants

    Introduction: Parkinson's disease (PD) research is hampered by slow, inefficient recruitment and burdensome in-person assessments that may be challenging to conduct in a world affected by COVID-19…
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    α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease

    Background: Extracellular vesicles are small vesicles that are released from many cells, including neurons. α-Synuclein has recently been described in extracellular vesicles derived from the central…
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    Hispanic perspectives on Parkinson's disease care and research participation

    Background: Hispanics are under-represented in Parkinson's disease (PD) research despite the importance of diversity for results to apply to a wide range of patients. Objective: To investigate the…
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    Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease

    Objective: The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease. Methods: We performed the…
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Breaking Research Updates

Read the latest developments in the field’s understanding and treatment of Parkinson’s disease.

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