6701 - 6750 of 8654 Results
Title
Year
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OPENTitle: PathoFact: a pipeline for the prediction of virulence factors and antimicrobial resistance genes in metagenomic dataJournal Name: MicrobiomePublisher: Springer Science and Business Media LLCVol: 9Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40168-020-00993-9Best OA location URL: https://doi.org/10.1186/s40168-020-00993-9Citation Count: 145
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OPENTitle: Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's diseaseJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 64Issue #:Start Page: 79End Page: 87Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1016/j.nbd.2013.12.011Best OA location URL: https://doi.org/10.1016/j.nbd.2013.12.011Citation Count: 81
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OPENTitle: Tissue engineered nigrostriatal pathway for treatment of Parkinson's diseaseJournal Name: Journal of Tissue Engineering and Regenerative MedicinePublisher: WileyVol: 12Issue #: 7Start Page: 1702End Page: 1716Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/term.2698Best OA location URL: https://europepmc.org/articles/pmc6416379?pdf=renderCitation Count: 58
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OPENTitle: Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencingJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-019-0873-5Best OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-019-0873-5Citation Count: 41
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OPENTitle: Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network levelJournal Name: Brain Research BulletinPublisher: Elsevier BVVol: 220Issue #:Start Page: 111169End Page: 111169Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.brainresbull.2024.111169Best OA location URL: https://doi.org/10.1016/j.brainresbull.2024.111169Citation Count: 0
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OPENTitle: A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brainJournal Name: eLifePublisher: eLife Sciences Publications, LtdVol: 7Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.7554/elife.40202Best OA location URL: https://doi.org/10.7554/elife.40202Citation Count: 238
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OPENTitle: Denitrogenative Alkylation of K-Ras(G12D) Inhibits Oncogenic Signaling in Cancer CellsJournal Name: Journal of the American Chemical SocietyPublisher: American Chemical Society (ACS)Vol: 147Issue #: 28Start Page: 24785End Page: 24792Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1021/jacs.5c06745Best OA location URL: https://doi.org/10.1021/jacs.5c06745Citation Count: 0
- Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors2011RESTRICTEDTitle: Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitorsJournal Name: Pharmacological ResearchPublisher: Elsevier BVVol: 64Issue #: 3Start Page: 268End Page: 273Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.phrs.2011.03.017Citation Count: 52
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OPENTitle: Spring is in the air: seasonal profiles indicate vernal change of miRNA activityJournal Name: RNA BiologyPublisher: Informa UK LimitedVol: 16Issue #: 8Start Page: 1034End Page: 1043Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/15476286.2019.1612217Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/15476286.2019.1612217?needAccess=trueCitation Count: 15
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RESTRICTEDTitle: Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson’s diseaseJournal Name: Clinical Autonomic ResearchPublisher: Springer Science and Business Media LLCVol: 29Issue #: 6Start Page: 603End Page: 614Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s10286-019-00632-wBest OA location URL: https://escholarship.org/content/qt5zh861v7/qt5zh861v7.pdf?t=qa7xspCitation Count: 16
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OPENTitle: Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s diseaseJournal Name: Journal of NeuroinflammationPublisher: Springer Science and Business Media LLCVol: 14Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12974-017-0935-1Best OA location URL: https://doi.org/10.1186/s12974-017-0935-1Citation Count: 82
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OPENTitle: Is the MC1R variant p.R160W associated with Parkinson's?Journal Name: Annals of NeurologyPublisher: WileyVol: 79Issue #: 1Start Page: 159End Page: 161Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/ana.24527Best OA location URL: http://doi.org/10.1002/ana.24527Citation Count: 18
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OPENTitle: Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementiaJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 9Issue #: 2Start Page: 106End Page: 121Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.51482Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51482Citation Count: 35
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RESTRICTEDTitle: Oxidative Damage in Parkinson's DiseaseJournal Name: Antioxidants & Redox SignalingPublisher: Mary Ann Liebert IncVol: 7Issue #: 5-6Start Page: 627End Page: 629Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1089/ars.2005.7.627Citation Count: 27
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OPENTitle: Development and In Vitro Characterization of [3H]GMC-058 as Radioligand for Imaging Parkinsonian-Related ProteinopathiesJournal Name: CellsPublisher: MDPI AGVol: 14Issue #: 12Start Page: 869End Page: 869Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/cells14120869Best OA location URL: https://www.mdpi.com/2073-4409/14/12/869/pdf?version=1749469748Citation Count: 0
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OPENTitle: Creating a patient‐centered guide to navigating cognitive change in Parkinson’s diseaseJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 16Issue #: S8Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/alz.041115Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.041115Citation Count: 0
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OPENTitle: Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicityJournal Name: BMC NeurosciencePublisher: Springer Science and Business Media LLCVol: 21Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12868-020-00582-4Best OA location URL: https://bmcneurosci.biomedcentral.com/track/pdf/10.1186/s12868-020-00582-4Citation Count: 28
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OPENTitle: Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or SeverityJournal Name: Movement DisordersPublisher: WileyVol: 37Issue #: 1Start Page: 190End Page: 195Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mds.28792Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/9292990Citation Count: 28
- Oral Transport, Penetration, and Aspiration in PD: Insights from a RCT on STN + SNr Stimulation2024RESTRICTEDTitle: Oral Transport, Penetration, and Aspiration in PD: Insights from a RCT on STN + SNr StimulationJournal Name: DysphagiaPublisher: Springer Science and Business Media LLCVol: 40Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s00455-024-10779-yCitation Count: 0
- Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice2018OPENTitle: Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceJournal Name: Science Translational MedicinePublisher: American Association for the Advancement of Science (AAAS)Vol: 10Issue #: 465Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/scitranslmed.aah4066Citation Count: 719
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OPENTitle: VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sitesJournal Name: Journal of Cell BiologyPublisher: Rockefeller University PressVol: 217Issue #: 10Start Page: 3625End Page: 3639Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-sa, cc-by-nc-saDOI - Digital Object Identifier: 10.1083/jcb.201807019Best OA location URL: https://rupress.org/jcb/article-pdf/217/10/3625/1378265/jcb_201807019.pdfCitation Count: 527
- A dual-functional substrate for quantitation of substrate levels and GCase activity in living cells2025OPENTitle: A dual-functional substrate for quantitation of substrate levels and GCase activity in living cellsJournal Name: RSC Chemical BiologyPublisher: Royal Society of Chemistry (RSC)Vol: 6Issue #: 8Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1039/d5cb00045aBest OA location URL: https://pubs.rsc.org/en/content/articlepdf/2025/cb/d5cb00045aCitation Count: 0
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OPENTitle: Sequence of clinical and neurodegeneration events in Parkinson’s disease progressionJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 144Issue #: 3Start Page: 975End Page: 988Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1093/brain/awaa461Best OA location URL: https://academic.oup.com/brain/article-pdf/144/3/975/37036706/awaa461.pdfCitation Count: 83
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OPENTitle: Sex differences in LRRK2 G2019S and idiopathic Parkinson's DiseaseJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 4Issue #: 11Start Page: 801End Page: 810Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.489Best OA location URL: https://escholarship.org/uc/item/61z1w0rnCitation Count: 35
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RESTRICTEDTitle: P1‐021: Diurnal and intersubject variability of cerebrospinal fluid biomarkers, Aβ‐40/42, alpha‐synuclein and DJ‐1 in healthy volunteersJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 8Issue #: 4S_Part_3Start Page:End Page:Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jalz.2012.05.296Citation Count: 0
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RESTRICTEDTitle: Machine learning methods for optimal prediction of motor outcome in Parkinson’s diseaseJournal Name: Physica MedicaPublisher: Elsevier BVVol: 69Issue #:Start Page: 233End Page: 240Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.ejmp.2019.12.022Citation Count: 41
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RESTRICTEDTitle: A biobank for Parkinson's disease and atypical parkinsonism in central Asian and Transcaucasian regionsJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 23Issue #: 9Start Page: 859End Page: 860Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(24)00313-2Citation Count: 2
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OPENTitle: Deep Brain Stimulation associated gliosis: A post-mortem studyJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 54Issue #:Start Page: 51End Page: 55Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.04.009Citation Count: 29
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OPENTitle: Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s diseaseJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-018-0596-zBest OA location URL: https://doi.org/10.1186/s40478-018-0596-zCitation Count: 72
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RESTRICTEDTitle: Cerebrospinal fluid hemoglobin levels as markers of blood contamination: relevance for α-synuclein measurementJournal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Publisher: Walter de Gruyter GmbHVol: 59Issue #: 10Start Page: 1653End Page: 1661Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1515/cclm-2020-1521Citation Count: 6
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OPENTitle: Intestinal biomarkers, microbiota composition, and genetic predisposition to inflammatory bowel disease as predictors of Parkinson's disease manifestationJournal Name: Journal of Parkinson’s DiseasePublisher: SAGE PublicationsVol: 15Issue #: 4Start Page: 766End Page: 779Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1177/1877718x251328567Best OA location URL: https://doi.org/10.1177/1877718x251328567Citation Count: 0
- A Failed Future2020OPENTitle: A Failed FutureJournal Name: Movement DisordersPublisher: WileyVol: 35Issue #: 8Start Page: 1299End Page: 1301Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.28130Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.28130Citation Count: 4
- Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength2018OPENTitle: Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strengthJournal Name: Biomolecular NMR AssignmentsPublisher: Springer Science and Business Media LLCVol: 12Issue #: 1Start Page: 195End Page: 199Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s12104-018-9808-5Best OA location URL: https://europepmc.org/articles/pmc5877819?pdf=renderCitation Count: 16
- Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics2020OPENTitle: Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane DynamicsJournal Name: MoleculesPublisher: MDPI AGVol: 25Issue #: 11Start Page: 2561End Page: 2561Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/molecules25112561Best OA location URL: https://www.mdpi.com/1420-3049/25/11/2561/pdf?version=1591348343Citation Count: 4
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RESTRICTEDTitle: The novel 5-HT1A receptor agonist, NLX-112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurementsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 105Issue #:Start Page: 651End Page: 660Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2016.01.013Citation Count: 34
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RESTRICTEDTitle: Wearable Electrochemical Microneedle Sensor for Continuous Monitoring of Levodopa: Toward Parkinson ManagementJournal Name: ACS SensorsPublisher: American Chemical Society (ACS)Vol: 4Issue #: 8Start Page: 2196End Page: 2204Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1021/acssensors.9b01127Citation Count: 301
- Impact of oral textures on aspiration and changes in swallow dynamics in patients with PD with DBS2020RESTRICTEDTitle: Impact of oral textures on aspiration and changes in swallow dynamics in patients with PD with DBSJournal Name: Journal of Neurology, Neurosurgery & PsychiatryPublisher: BMJVol: 92Issue #: 4Start Page: 447End Page: 449Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1136/jnnp-2020-324579Citation Count: 0
- A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration2025OPENTitle: A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegenerationJournal Name: Nature CommunicationsPublisher: Springer Science and Business Media LLCVol: 16Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41467-025-56833-7Best OA location URL: https://doi.org/10.1038/s41467-025-56833-7Citation Count: 0
- Parkinson's disease‐associated dyskinesia in countries with low access to levodopa‐sparing regimens2019RESTRICTEDTitle: Parkinson's disease‐associated dyskinesia in countries with low access to levodopa‐sparing regimensJournal Name: Movement DisordersPublisher: WileyVol: 34Issue #: 12Start Page: 1929End Page: 1930Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.27891Citation Count: 5
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OPENTitle: Arm swing as a potential new prodromal marker of Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 31Issue #: 10Start Page: 1527End Page: 1534Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.26720Best OA location URL: http://doi.org/10.1002/mds.26720Citation Count: 163
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OPENTitle: Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal DepressionJournal Name: The American Journal of Geriatric PsychiatryPublisher: Elsevier BVVol: 25Issue #: 9Start Page: 980End Page: 991Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.jagp.2017.04.011Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/10079284Citation Count: 31
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OPENTitle: Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradationJournal Name: Science AdvancesPublisher: American Association for the Advancement of Science (AAAS)Vol: 7Issue #: 32Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1126/sciadv.abf6580Best OA location URL: https://doi.org/10.1126/sciadv.abf6580Citation Count: 30
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RESTRICTEDTitle: Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 40Issue #:Start Page: 83End Page: 84Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2017.05.001Citation Count: 7
- Identifying Protective Drugs for Parkinson's Disease in Health‐Care Databases Using Machine Learning2022OPENTitle: Identifying Protective Drugs for Parkinson's Disease in Health‐Care Databases Using Machine LearningJournal Name: Movement DisordersPublisher: WileyVol: 37Issue #: 12Start Page: 2376End Page: 2385Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1002/mds.29205Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.29205Citation Count: 10
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OPENTitle: Role of alpha-synuclein seed amplification assay in Parkinson’s disease clinical trials: A case of misdiagnosisJournal Name: Clinical Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 11Issue #:Start Page: 100274End Page: 100274Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.prdoa.2024.100274Best OA location URL: https://doi.org/10.1016/j.prdoa.2024.100274Citation Count: 1
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OPENTitle: Lifestyle factors and clinical severity of Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-023-31531-wBest OA location URL: https://www.nature.com/articles/s41598-023-31531-w.pdfCitation Count: 12
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OPENTitle: A Fixable Fluorescence‐Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed CellsJournal Name: Angewandte Chemie International EditionPublisher: WileyVol: 62Issue #: 40Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/anie.202309306Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202309306Citation Count: 9
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RESTRICTEDTitle: The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson diseaseJournal Name: Journal of NeurologyPublisher: Springer Science and Business Media LLCVol: 262Issue #: 11Start Page: 2443End Page: 2447Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s00415-015-7868-3Citation Count: 25
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OPENTitle: Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's DiseaseJournal Name: Movement DisordersPublisher: WileyVol: 38Issue #: 9Start Page: 1655End Page: 1667Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mds.29510Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.29510Citation Count: 15
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OPENTitle: Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated by α-synucleinJournal Name: Microsystems & NanoengineeringPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41378-020-0147-1Best OA location URL: https://escholarship.org/uc/item/6hk8q5kgCitation Count: 10