To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Eif4g1 KO
Mouse Model
Mice carrying a targeted Eif4g1 mutation in which exons 24 through 28 are deleted. RRID:IMSR_JAX:024521
Alpha-Synuclein Monomer Protein
Protein
Full-Length human alpha-synuclein monomeric protein generated in vitro.
Note: This protein was used to generate alpha-synuclein filament which was then used as antigen for the MJF-14 alpha-synuclein filament-specific antibody which is also available at Abcam.
Human Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-Length human alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
*Discontinued for fibrils lack of seeding activity.
Total Rab 8 Antibody (Hu/Ms/Rt)
Antibody
Rabbit monoclonal antibody directed against the human and rodent total Rab 8 protein. Suitable for immunoblot and immunoprecipitation experiments. This antibody epitope was mapped to C-terminus amino acids 190-196.
Alpha-Synuclein Filament Protein
Protein
Full-Length human alpha-synuclein protein expressed in vitro and manipulated to form alpha-synuclein filaments.
Note: This filament version of alpha-synuclein was used as antigen for the MJF-14 conformation-specific rabbit monoclonal alpha-synuclein filament-specific antibody which is available at Abcam. This protein is not intended for use as a pre-formed fibril for seeding alpha-synuclein pathology in vivo or in vitro. For protein to use in an alpha-synuclein pre-formed fibril model please use the "Human alpha-synuclein monomer protein for making pre-formed fibrils" available from Proteos.
LRRK2 Antibody (MJFF3)
Antibody
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
HdAd5 3xFLAG-LRRK2 (G2385R)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2385R mutation. HdAd5 FLAG-TK available as a control in Control section.
Full Length pS129 Alpha-Synuclein Protein
Protein
Phospho-S129 Alpha Synuclein semi-synthetic phosphomimetic protein generated by native chemical ligation of a recombinant peptide produced from E. coli and a synthtic peptide
DJ-1 proteins (recombinant proteins generated using an E. Coli expression system)
Protein
The following versions of recombinant DJ-1 protein generated using an E. coli expression system are available:
- Untagged DJ-1
- His-tagged DJ-1
- Oxidized DJ-1
DJ-1 proteins (recombinant proteins generated in a mammalian-optimized expression system)
Protein
The following versions of recombinant DJ-1 protein generated using a mammalian-optimized expression system are available:
- His-tagged DJ-1
- TEV-cleaved DJ-1
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic