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LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences
Marco A.S. Baptista1, Kalpana M. Merchant1, Sakshi Bharghava2, Diane Bryce3, Michael Ellis3, Anthony A. Estrada4, Matthew Fell3, Reina N. Fuji4, Paul Galatsis2, Sue Hill3, Warren D. Hirst2, Christopher Houle2, Matthew Kennedy3, Xingrong Liu4, Matthew Maddess3, Carrie Markgraf3, Hong Mei3, Elie Needle2, Stefan Steyn2, Zhizhang Yi3, Honghsi Yu3, Brian K. Fiske1, and Todd B. Sherer1
1MJFF, 2Pfizer, 3Merck, 4Genentech
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common...Read More
Kuldip D. Dave1, Adria K. Martig1, Terina N. Martinez1, Lee J. Pellegrino2, Leo B. Dungan2, Rick Hamler2, Sean W. Clark2, Peter D. Buckett3, Yi Chen3, Weisong Shan3, Warren D. Hirst3, Michael Sasner4, Mark Herberth5, Robert Switzer6, Todd B. Sherer1 and Brian K. Fiske1
1The Michael J. Fox Foundation, New York NY; 2Amicus Therapeutics, Cranbury, NJ; 3Pfizer, Boston, MA; 4The Jackson Laboratory, Bar Harbor, ME; 5WIL Research, Ashland, OH; 6NeuroScience Associates, Knoxville, TN.
Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and the safety implications of targeting LRRK2 kinase activity are not well understood. We evaluated the potential safety risks by comparing human and mouse LRRK2 mRNA tissue expression, by analyzing a Lrrk2 knockout mouse model, and by testing selective brain-penetrating LRRK2 ki...Read More
Use of an Online Portal to Facilitate Clinical Trial Recruitment: A Preliminary Analysis of Fox Trial Finder (Article)
Journal of Parkinsons Disease
An evaluation of Fox Trial Finder — MJFF's online tool that matches eligible volunteers to local, recruiting clinical trials — characterizes potential research volunteers and highlights gaps between research requirements and participants....Read More