The Michael J. Fox Foundation continually strives to communicate our scientific progress -- at meetings, as well as through peer-reviewed scientific publications.
The Michael J. Fox Foundationís Strategy to Generate, Characterize, and Distribute Preclinical Antibody Tools for Investigating Parkin/PINK1 and LRRK2- and PINK1-Related Rab Molecular Biology
November 17, 2017
Terina N. Martinez1, Meng-Yun Chou2, Dario R. Alessi3, Paul Davies3 Pawel Lis3, Miratul Muqit3, Michael G. Schlossmacher4, Peggy Taylor5, Brian O'Nuallain5, Jacqueline Tokarew4, Daniel El-Kodsi4, Julianna Tomlinson4, Shalini Padmanabhan1, Marco Baptista1, Nicole K. Polinski1, Kuldip D. Dave1
The Michael J. Fox Foundation for Parkinson's Research1, Abcam, Inc.2, University of Dundee3, Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Inst...Read More
The Michael J. Fox Foundationís Efforts to Generate, Characterize, and Promote the Use of a Variety of Preclinical Models of Parkinsonís Disease
November 17, 2017
Nicole K. Polinski1, Terina N. Martinez1, Lindsey Gottler2, Steve Marshall3, Kelvin C. Luk4, Caryl E. Sortwell5, Kelly Dakin6, Allesia Krank1, Amasi Kumeh1, Allison L. Morris1, Kuldip D. Dave1
The Michael J. Fox Foundation for Parkinson's Research1, Proteos, Inc.2, GeneDetect3, University of Pennsylvania4, Michigan State University5, AlzForum6.
Preclinical models are a necessary tool for investigating the pathogenesis and potential therapeutic strategies for diseases like Par...Read More
User's guide for alpha-synuclein biomarker studies in biological fluids: Perianalytical considerations
July 22, 2017
This article summarizes perianalytical considerations for biomarker studies (based on immunoassays) in Parkinson's disease, with emphasis on quantifying total α-synuclein protein in biological fluids. Current knowledge and pitfalls are discussed, and selected perianalytical variables are presented systematically, including different temperature of sample collection and types of collection tubes, gradient sampling, the addition of detergent, aliquot volume, the freezing ti...Read More