The Michael J. Fox Foundation continually strives to communicate our scientific progress – at meetings, as well as through peer-reviewed scientific publications.
Science Translational Medicine
Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and the safety implications of targeting LRRK2 kinase activity are not well understood. We evaluated the potential safety risks by comparing human and mouse LRRK2 mRNA tissue expression, by analyzing a Lrrk2 knockout mouse model, and by testing selective brain-penetrating ...Read More
Use of an Online Portal to Facilitate Clinical Trial Recruitment: A Preliminary Analysis of Fox Trial Finder (Article)
Journal of Parkinsons Disease
An evaluation of Fox Trial Finder — MJFF's online tool that matches eligible volunteers to local, recruiting clinical trials — characterizes potential research volunteers and highlights gaps between research requirements and participants.Read More