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Biospecimens

The Michael J. Fox Foundation makes data and biospecimens available from select Parkinson’s studies for discovery and validation research. Visit our Data page for resources from these and other studies. We also fund promising projects that use these data and biospecimen collections.

15 Types of Samples Available

  • Parkinson’s Progression Markers Initiative
    Population:
    De novo, unmedicated PD; prodromal; genetic; controls
    Request Samples For:
    Biomarker validation; Disease Progression; Understand genetic PD
    Cohort Size
    1,500+

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • BioFIND
    Population:
    Moderate to advanced PD and controls
    Request Samples For:
    Biomarker Discovery; Biomarker Replication
    Cohort Size
    ~200

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • LRRK2 Cohort Consortium
    Population:
    Genetic
    Request Samples For:
    Biomarker Discovery; Biomarker Replication; Disease Progression; Understand genetic PD
    Cohort Size
    3,200

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • DATATOP
    Population:
    Early, unmedicated PD
    Request Samples For:
    Biomarker Discovery; Biomarker Replication; Disease Progression; Pharmacogenetics/pharmacodynamics;
    Cohort Size
    800

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • 24-Hour Biofluid Sampling
    Population:
    Early to moderate PD and controls
    Request Samples For:
    Assay development/ validation; Biomarker Discovery; Biomarker Replication; Diurnal fluctuation
    Cohort Size
    ~30

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • Arizona Parkinson's Disease Consortium
    Population:
    PD, other neurodegenerative diseases, neurologically normal elderly controls
    Request Samples For:
    Clinicopathological correlations
    Cohort Size
    450

    • Postmortem CSF

    • Postmortem Blood

    • Postmortem Tissue

  • LRRK2 PBMC & Urine Biobank
    Population:
    iPD, LRRK2 PD (G2019S only), LRRK2 NMC, Healthy Controls
    Request Samples For:
    Assay development/ validation; Biomarker Discovery; Biomarker Replication; Biomarker validation; Understand genetic PD

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • S4
    Population:
    81 subjects comprising of early, moderate, advanced Parkinson's Disease patients and Healthy Controls
    Request Samples For:
    Biomarker Discovery; Biomarker Replication; Biomarker validation

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • STEADY PD - 3
    Population:
    336 subjects with early idiopathic PD not requiring dopaminergic therapy
    Request Samples For:
    Pharmacogenetics/pharmacodynamics

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • SURE PD - 3
    Population:
    298 Individuals with early Parkinson's Disease
    Request Samples For:
    Pharmacogenetics/pharmacodynamics

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • SURE PD - Phase 2
    Population:
    75 individuals with early Parkinson's Disease
    Request Samples For:
    Pharmacogenetics/pharmacodynamics

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • PARS
    Population:
    300 individuals over 50 without a diagnosis of PD or other neurological disorder at enrollment
    Request Samples For:
    Biomarker Replication; Biomarker validation; Disease Progression;

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • FS-Zone
    Population:
    217 subjects with early Parkinson's Disease
    Request Samples For:

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • CERE-120
    Population:
    147 individuals with Parkinson's Disease
    Request Samples For:
    Cohort Size
    ~150

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

  • AVE-8112
    Population:
    13 individuals with Parkinson's Disease
    Request Samples For:
    Cohort Size
    13

    • DNA

    • RNA

    • CSF

    • Whole or Pellet Blood

    • Plasma

    • Serum

    • Urine

    • Saliva

    • Peripheral Mononuclear Blood Cells

    • Fibroblasts

    • Induced Pluripotent Stem Cells

    • Skin Tissue

    • Colon Tissue

    • Sub-Mandibular Gland Tissue

Female researcher pipetting in lab.

Breaking Research Updates

Read the latest developments in the field’s understanding and treatment of Parkinson’s disease.

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