Ted M. Dawson, MD, PhD
Director, Institute for Cell Engineering; Director, Morris K. Udall Parkinson's Disease Research Center; Interim Director, Movement Disorder Division and the Parkinson's Disease and Movement Disorder Center; Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases; Professor, Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences at Johns Hopkins University School of Medicine
Location: Baltimore, Maryland, United States
Dr. Ted Dawson is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases and Director of the Institute for Cell Engineering at the Johns Hopkins University School of Medicine. Dr. Dawson is also director of the NINDS Morris K. Udall Parkinson's Disease Center of Excellence at Johns Hopkins University.
His laboratory is interested in the molecular mechanisms by which neurons die in neurologic and neurodegenerative diseases. Dr. Dawson discovered parthanatos and defined the mechanism by which glutamate excitoxicity kills neurons through nitric oxide mediated activation of poly [ADP-ribose] (PAR) polymerase (PARP) and release of apoptosis inducing factor (AIF) and the nuclease activity of the parthanatos AIF-associated nuclease.
Dr. Dawson is also at the forefront of research into the molecular mechanisms of the neurodegenerative process of Parkinson's disease. He is a member of the Association of American Physicians and a fellow of the American Association for the Advancement of Science.
- Evaluation of PARIS ASOs in Models of Parkinson's Disease (2018)
- Evaluation of PARIS (ZNF746) as a Target of Alpha-synuclein Toxicity in Parkinson's Disease and Alpha-synucleinopathies (2016)
- Identification and Validation of the Modifiers of LRRK2-induced Toxicity (2010)
- Generation of Transgenic Mice with Selective and Progressive Loss of Nigrostriatal Dopaminergic Neurons (2006)
- Generation and Characterization of Mice with Inducible and Cell-Type Specific Interruption ofGDNF Signaling (2004)