The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Biomarkers, 2010Oxidized DJ-1 as a Biomarker for Parkinson's Disease
Objective/Rationale:
Mutations in the DJ-1 gene are associated with an early-onset familial form of PD and DJ-1 protein has been shown to be decreased in the CSF of sporadic PD compared to controls. ... -
Target Validation, 2010Pharmacological PHD Inhibition as a Potential PD Neuroprotectant Therapy
Objective/Rationale:
A growing body of evidence suggests that iron dysregulation may contribute to neurodegeneration associated with Parkinson’s disease (PD). Recent work from our laboratory suggests... -
Target Validation, 2010VEGF-B - A New Neurotrophic Factor for Treatment for Parkinson's Disease
Objective/Rationale:
We discovered that the vascular endothelial growth factor, VEGF-B, acts as a natural response of brain cells to a neurotoxin that produces Parkinson’s disease in pre-clinical... -
Target Validation, 2010mTORC1 as a Target for the Treatment of Levodopa-induced Dyskinesia
Objective/Rationale:
The choreic and dystonic movements, or dyskinesia, which develop in response to prolonged treatment with levodopa, represent one of the major limitations to the current therapy... -
Target Validation, 2010Peroxisome-Proliferator Activated Receptor gamma as a Target for Anti-Dyskinesia Pharmacotherapy
Objective/Rationale:
We plan to develop new pharmacological approaches to treat levodopa-induced dyskinesia (LID) in a pre-clinical model of Parkinson’s disease (PD). Preliminary data from our... -
Target Validation, 2010Targeting the Unfolded Protein Response (UPR) Transcription Factor XBP-1 to Treat Parkinson's Disease
Objective/Rationale:
Our general objective is to investigate the role of a specific component of a cellular stress responses linked to organelle damage, the Unfolded Protein Response (UPR), in the...
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