The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2012Mechanisms of Parkin Recruitment and Mitophagy
Promising Outcomes of Original Grant:
The protein Parkin is thought to be required for the maintenance of healthy mitochondria, critical subcellular organelles that govern cellular energy production... -
Rapid Response Innovation Awards, 2012Is the Xenomitochondrial Pre-clinical model an ‘Ideal’ Parkinson’s Disease Model?
Objective/Rationale:
The lack of a pre-clinical model that exhibits key features of human Parkinson’s disease is an impediment to research progress. In this project we will determine whether a novel... -
Rapid Response Innovation Awards, 2012Mifunctional Cembranoids for Therapy of Parkinson’s Disease
Objective/Rationale:
Although considerable achievements have been made in the understanding of pathophysiology of Parkinson’s disease (PD), there are still limited effective approaches available for... -
Therapeutics Development Initiative, 2011Testing of Ambroxol in the Thy1-Alpha-Synuclein Pre-clinical Model of Parkinson's disease
Objective/Rationale:
Biochemical evidence suggests that blocking the maturation of a natural enzyme, glucocerebrosidase (GCase), can cause the build-up of alpha-synuclein deposits in neurons. Such... -
Dyskinesia Challenge, 2012The Effects of Memantine on Levodopa Induced Dyskinesias (LIDs) in MPTP-treated Pre-clinical Models
Objective/Rationale:
Levodopa is the mainstay of treatment for the motor symptoms of Parkinson’s disease. Unfortunately one of the long term side effects of levodopa treatment is the development of... -
Rapid Response Innovation Awards, 2012Functional Integration of Grafted Human Induced Neuronal (iN) Cells in Parkinson's Disease
Objective/Rationale:
Recently, genetic manipulation of human cells from various organs, e.g. skin, enabled direct generation of human nerve cells (so-called induced neurons – iNs) that potentially can...
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Our funding programs support basic, translational and clinical research from academia and industry.