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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2026
    Deep Mutational Scanning of TMEM175

    Study Rationale:                   

    Parkinson’s disease develops through a combination of ageing, environmental factors, and genetic risk. One gene linked to Parkinson’s is TMEM175, which encodes an...

  • Research Grant, 2026
    Cell Type Meta-eQTL Study in Human Brains

    Study Rationale:                                                

    Parkinson’s (PD) genome-wide association study (GWAS) with ~1.5 million subjects identified 90 PD risk signals with ~7,000 non-coding PD...

  • Research Grant, 2026
    Genetically Encoded Fluorescent Biosensors for Live-cell, Subcellular Detection of Distinct α-synuclein Aggregation States

    Study Rationale:                   

    Alpha-synuclein (aSYN) is a critical protein in health and Parkinson’s disease (PD). aSYN has a soluble form and a series of increasingly aggregated forms. These...

  • Spring 2025 RFP: Accelerating Biological Understanding and Therapeutic Translation for PD-Biomarkers, 2026
    Oxylipin Profiles in LRRK2 Mutation Carriers: Biomarkers for Parkinson’s Disease

    Study Rationale:                   

    Parkinson’s disease (PD) involves complex interactions between genetic factors, such as LRRK2 mutations, and lipid metabolism. Oxylipins, bioactive lipid mediators...

  • Research Grant, 2026
    Including a Watch to the Gait Substudy

    Aims and Hypothesis:

    Here we propose to leverage the gait sub-study and add a watch to a subset of participants who are anticipated to return for their second gait assessment. Such addition will enable...

  • Parkinson’s Disease Therapeutics Pipeline Program -Pre-Clinical, 2026
    CSM-101 TRPML1 Agonist for Parkinson’s Disease

    Study Rationale:                   

    The appropriate regulation of proteins and lipids within neurons is critical for human health. Lysosomes are specialized structures within cells that are responsible...

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