The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Community Fast Track, 2004Cytoprotective role of ABAD in Parkinson disease
Mitochondrial dysfunction and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the features of Parkinson's disease (PD). We have identified a multifunctional member of the...
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Community Fast Track, 2004Alpha-synuclein and Environmental Exposures: A Study in Humans
The long-term goal of this research is to find the cause or causes of typical, late-onset sporadic Parkinson's disease (PD). To date the search for genetically determined risk factors that could...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Identification of Novel Determinants for Dopamine Neuron Generation in Vivo and in Embryonic Stem Cells
Understanding how the different cells of the brain are generated during embryonic development is one of the fundamental questions in biology. Recent studies have elucidated several key mechanisms...
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MJFF Research Grant, 2004Simple Blood Tests for Parkinson's Disease Derived from Genome-wide Expression Changes
In work from their initial grant, Drs. Steven Gullans and Clemens Scherzer at Brigham and Women’s Hospital identified a number of genes that are differentially expressed in blood cells of patients...
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The Role of Inflammation in Parkinson's Disease, 2004The role of TNF-mediated dopaminergic neurotoxicity in Parkinson's disease: Novel anti-TNF biologics as biochemical tools and new therapeutic agents
In July 2004, at the one-year assessment of our initial grant under the Foundation's Inflammation initiative, we demonstrated that our novel dominant-negative TNFs offered significant in vivo...
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The Role of Inflammation in Parkinson's Disease, 2003Inflammatory Mechanisms & PD Risk: A Discordant Twin Pairs Case-Control Study
The cause of Parkinson’s disease is unknown. A genetic cause is identified in only a small percentage of cases. We believe that environmental factors play an important role in most cases of PD. While...
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Our funding programs support basic, translational and clinical research from academia and industry.