The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2013Bach1 and Bach2 Inhibit Nrf2 Antioxidant Responses in Substantia Nigra Neurons
Objective/Rationale:
Oxidative stress and damage are well-known contributors in the pathogenesis of Parkinson’s disease (PD). To combat oxidative damage, transcription factor Nrf2... -
Research Grant, 2013LRRK2 Effects on Neural Differentiation (Supplement 2)
Promising Outcomes of Original Grant:
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) account for up to 13% of familial Parkinson's disease (PD) patients, but the function of LRRK2... -
LRRK2 Challenge, 2013Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking 2013
Objective/Rationale:
Synapses provide a connection that allows signals to travel between neurons. Pre-clinical research showed that the LRRK2 kinase may influence synaptic function through effects on... -
Biosample and Tissue Resource, 2013Discovery of Changes in N-linked Glycans Associated with Parkinson’s Disease
Objective/Rationale:
The objective of this study is to explore the role of glycans (sugars attached to proteins) in the development and progression of Parkinson’s disease (PD). Glycans... -
LRRK2 Challenge, 2013Investigation of LRRK2 as a Regulator of Microglial Cell Function
Objective/Rationale:
Mutations of the LRRK2 gene are associated with Parkinson’s disease (PD), but very little is known about how or where the LRRK2 kinase normally functions in the brain... -
Cognition Biomarkers, 2013Identification and Validation of Cerebrospinal Fluid Markers Related to Altered Amyloid-beta Processing in the Prediction of Dementia Associated with Parkinson’s Disease
Objective/Rationale:
Patients with Parkinson’s disease (PD) are at increased risk to develop dementia compared with the general population. However, not all patients experience this...
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Our funding programs support basic, translational and clinical research from academia and industry.