The Michael J. Fox Foundation has prioritized alpha-synuclein imaging as the most likely imaging approach to have an impact for therapeutic development. The goal of this $10-million funding program is to deliver a selective alpha-synuclein PET tracer for use in clinical studies.
The Michael J. Fox Foundation (MJFF) is issuing this request for applications (RFA) for investigator-initiated studies to accelerate development of a selective alpha-synuclein PET tracer. We encourage multidisciplinary teams to apply to this program and are particularly interested in collaborations between academic and industry groups that have access to diverse compound libraries.
Projects can include compound screening, tissue binding studies, lead identification and optimization, in vivo testing in appropriate models, and first-in-human testing of candidate tracers. Funding prioritization will be given to those teams that show the greatest promise for delivering a selective tracer for human testing at the end of the funding period.
The total amount of funding available for this program is $10 million. A total of $8.5 million is available for the first two years of the program with the possibility of an additional $1.5 million for the project that shows the most promising results during the initial funding period. These budgets include direct and indirect costs.
In addition, these teams may be eligible for our Alpha-synuclein Imaging Prize. MJFF has pledged $2 million to the first team to show clinical evidence of a selective alpha-synuclein PET tracer and to agree to make the tool available to the research community.
This program is made possible in part through the generous support of Ken Griffin, Founder and CEO of the Chicago-based global investment firm Citadel. Read a press release on this funding program and its support.
Watch a webinar to learn more about our Foundation's funding strategy, this competition, and the application and review processes.
1. Download RFA overview and proposal template.
2. Log in or create account in the grant application portal.
3. Submit your completed application.
Contact firstname.lastname@example.org with questions.