Anna Krichevsky, PhD

Dr. Anna Krichevsky is a Professor of Neurology at Brigham and Women’s Hospital and Harvard Medical School. As a postdoctoral fellow, she carried out pioneering studies that helped establish microRNAs and RNA interference as central regulators of brain biology. Her work includes the isolation of neuronal RNA granules, the first successful RNA interference in mammalian neurons, development of the first high-throughput miRNA expression platform, the identification of brain-specific microRNAs, and discovery of key regulatory RNAs- including miR-21, miR-10b, miR-132, and the enhancer HOXDeRNA. Dr. Krichevsky’s laboratory investigates diverse regulatory RNAs, both small and long noncoding, as fundamental drivers of brain pathology, with an emphasis on neurodegenerative and malignant disorders. Her research spans discovery of novel RNA regulators, RNA-centered disease hubs, extracellular RNA biology, and translation of RNA-targeting strategies toward first-in-human therapies. She is a recipient of numerous awards and honors and co-directs the Harvard Initiative for RNA Medicine.