Dr. Howard E. Gendelman is the Margaret R. Larson Professor of Internal Medicine and Infectious Diseases, chairman of the Department of Pharmacology and Experimental Neuroscience and director of the Center for Neurodegenerative Disorders at the University of Nebraska Medical Center. Dr. Gendelman is credited with unraveling how functional alterations in brain immunity induce metabolic changes and ultimately lead to neural cell damage across a broad range of infectious, metabolic and neurodegenerative disorders. These discoveries have had broad implications on developmental therapeutics aimed at preventing, slowing or reversing neural maladies. He is also credited with demonstrating that AIDS dementia is a reversible metabolic encephalopathy. His work has led to novel immunotherapy strategies for Parkinson's disease that have been successfully tested in early clinical trials as a result of translational investigations. This current project is an extension of those previous studies.