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Funded Studies

Kostas Vekrellis, PhD

Researcher & Assistant Professor at Center for Basic Research, Biomedical Research Foundation of the Academy of Athens

Location: Athens Greece

Kostas Vekrellis received his BSc and PhD in neuroscience from University College London, UK. Dr. Vekrellis is a professor in neurobiology in the Division of Basic Research at the Biomedical Research Foundation of the Academy of Athens (BRFAA). He has extensive experience in cellular and animal models of neurodegeneration, particularly related to Parkinson’s disease (PD). He has provided evidence that alpha-synuclein also acts extracellularly, via active release from neurons, raising the possibility that these aggregates can exert effects on otherwise healthy cells. His lab uses a variety of models to investigate mechanisms of secretion and clearance of extracellular alpha-synuclein, which might be targets for therapy. His work also focuses on exploring the role of secreted alpha-synuclein in the spread of pathology between neurons and glia in the PD brain.


Associated Grants

  • Validation of KLK6 as a New Therapeutic Target for Parkinson’s Disease

    2023


  • Searching for and Targeting Calcium Channels that Control Alpha-synuclein Release

    2018


  • Anti-inflammatory Role of Activin-A in Protection against Alpha-synuclein-mediated Pathology

    2015


  • Investigation of the Mechanisms Involved in Alpha-synuclein Secretion In Vivo

    2012


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