Dr. Huang is a board-certified research neurologist whose clinical practice and scholarly concentrations are focused on Parkinson’s disease (PD) and related neurodegenerative disorders. She has a strong interest in translational neuroscience and her major focus is the use of novel imaging methods and designs to trace the changes in neurocircuitry underlying PD signs and symptoms, and to develop biomarkers for PD and related disorders. During her training in biomedical research (funded by a K23 award), Dr. Huang recognized that longitudinal studies could be extraordinarily powerful in understanding structural changes that occur as PD progresses. This led to her first NIH R01 grant (Structural MRI markers for PD) and a subsequent U01 grant (Multimodal MRI markers for PD progression). The U01 project collected the biofluids and data that will be utilized for the current proposal. Dr. Huang will serve as the co-PI of the overall project and Site PI for HMC.