-
-
Protective Effect of Immune Gene Subtype in Parkinson’s Disease
… effect of an immune gene called HLA-DR, specifically the presence of the HLA-DRB1*04 subtype. We found that HLA-DRB1*04 binds specifically to a part of alpha-synuclein, the protein enriched in Lewy … to DRB1*04 and use these fragments to isolate, analyze and compare the alpha-synuclein reactive immune T cells from PD …
-
(SUPPLEMENT) Enhancing Brain Clearance Mechanisms to Limit Parkinson Disease Progression
… the research from a prior grant: Using Sleep Modulation to Enhance the Brain’s Waste Clearance Mechanisms as an … to this finding is the fact that sleep disruptions are common in people with Parkinson’s, which have been shown to … toxic proteins in the brain. In this study, we will use a pre-clinical model of Parkinson disease to investigate how …
-
Improving Access to Depression Care in Parkinson’s Disease: A Telehealth Approach
… There is a critical need for treatments that address depression and barriers to care among the approximately 5 million people living with … disease (PD) worldwide. The purpose of this research is to test a new treatment (Telephone-Administered Cognitive … Depression …
-
Using LRRK2 Computer Simulations to Identify Therapeutic Targets for Parkinson's Disease
… proteins and alters several molecular pathways, including autophagy (cell break down), mitochondria (powerhouses of the … packets) and membrane (outside layer) and synaptic (site of communications) changes. To successfully identify … of mutant LRRK2. Promising targets will be validated using pre-clinical models of PD. Hypothesis: We hypothesize that …
-
Five Reasons to Be at the 2017 Parkinson's Unity Walk
March 3, 2017
… On Saturday, April 22, thousands of walkers are expected to gather at the 2017 Parkinson's Unity Walk in New York … the Parkinson's Unity Walk is a way to help the Parkinson's community move closer to a cure. While there have been … have the opportunity to learn about disease management by visiting the booths of Parkinson's organizations, healthcare …